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Tdark
LRCH3
Leucine-rich repeat and calponin homology domain-containing protein 3

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334859
  • ENSP00000334375
  • ENSG00000186001
  • ENST00000414675
  • ENSP00000394965
  • ENST00000425562
  • ENSP00000393579
  • ENST00000428136
  • ENSP00000394763
  • ENST00000438796
  • ENSP00000399751
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.66
kinase perturbation
0.66
tissue
0.63
cell type or tissue
0.6
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.01   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.01   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
DOCK8
Tbio
Novelty:  0.0067047
p_int:  1
Score:  0.863
Data Source:  BioPlex,STRINGDB
DOCK6
Tbio
Novelty:  0.01111596
p_int:  1
Score:  0.831
Data Source:  BioPlex,STRINGDB
LRCH1
Tbio
Novelty:  0.0923291
p_int:  0.999999676
p_ni:  2e-9
p_wrong:  3.23e-7
Score:  0.878
Data Source:  BioPlex,STRINGDB
DOCK7
Tbio
Novelty:  0.03425586
p_int:  0.999999533
p_ni:  4.67e-7
Score:  0.785
Data Source:  BioPlex,STRINGDB
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.999998186
p_ni:  0.000001814
Score:  0.21
Data Source:  BioPlex,STRINGDB
LRCH2
Tdark
Novelty:  1.90908316
p_int:  0.999997669
p_ni:  0.000002197
p_wrong:  1.34e-7
Score:  0.659
Data Source:  BioPlex,STRINGDB
VCPIP1
Tbio
Novelty:  0.09915033
p_int:  0.999975326
p_ni:  0.000024671
p_wrong:  2e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.998405122
p_ni:  0.001594878
Data Source:  BioPlex
LRCH4
Tbio
Novelty:  0.10751018
p_int:  0.998404035
p_ni:  0.000001023
p_wrong:  0.001594942
Score:  0.876
Data Source:  BioPlex,STRINGDB
DYRK1A
Tchem
Family:  Kinase
Novelty:  0.00226963
p_int:  0.996618097
p_ni:  0.003381899
p_wrong:  4e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and calponin homology domain containing 3
VGNC:11980
460972
Macaque
leucine rich repeats and calponin homology domain containing 3
722180
Mouse
MGI:1917394
70144
Rat
RGD:1306200
303883
Dog
leucine rich repeats and calponin homology domain containing 3
VGNC:53078
100687340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and calponin homology domain containing 3
Macaque
leucine rich repeats and calponin homology domain containing 3
Mouse
Rat
Dog
leucine rich repeats and calponin homology domain containing 3
Publication Statistics
PubMed Score 1.01
PubMed score by year
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Related Publications
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PMID
Year
Title