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Tdark
LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

Protein Summary
Description
This gene encodes a member of the leucine-rich repeat and calponin homology domain-containing protein family. These family members contain multiple N-terminal leucine-rich repeats, in addition to a C-terminal calponin homology domain, a type of domain that mediates interactions with actin filaments. These proteins are conserved across animal species, and studies of a similar Drosophila protein indicate a function as a cytoskeletal scaffolding protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317135
  • ENSP00000325091
  • ENSG00000130224
  • ENST00000538422
  • ENSP00000439366

Symbol
  • KIAA1495
  • dA204F4.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
gene perturbation
0.83
microRNA
0.6
interacting protein
0.52
histone modification site profile
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.43   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.43   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
LRCH1
Tbio
Novelty:  0.0923291
p_int:  0.999999946
p_ni:  3.6e-8
p_wrong:  1.9e-8
Data Source:  BioPlex
DOCK8
Tbio
Novelty:  0.0067047
p_int:  0.999999881
p_ni:  1.19e-7
Score:  0.816
Data Source:  BioPlex,STRINGDB
LRCH3
Tdark
Novelty:  1.02650989
p_int:  0.999997669
p_ni:  0.000002197
p_wrong:  1.34e-7
Score:  0.659
Data Source:  BioPlex,STRINGDB
MOB1B
Tbio
Family:  Enzyme
Novelty:  0.0718959
p_int:  0.999762932
p_ni:  0.000237068
Score:  0.229
Data Source:  BioPlex,STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
p_int:  0.999584127
p_ni:  0.000415871
p_wrong:  2e-9
Score:  0.638
Data Source:  BioPlex,STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.997167771
p_ni:  0.002832227
p_wrong:  2e-9
Data Source:  BioPlex
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.963092701
p_ni:  0.036475782
p_wrong:  0.000431516
Data Source:  BioPlex
NPRL2
Tbio
Family:  Enzyme
Novelty:  0.02848752
p_int:  0.929402196
p_ni:  0.07005366
p_wrong:  0.000544144
Score:  0.188
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.887012987
p_ni:  0.112872792
p_wrong:  0.000114221
Data Source:  BioPlex
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.843179347
p_ni:  0.155570489
p_wrong:  0.001250164
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
leucine rich repeats and calponin homology domain containing 2
708436
Mouse
MGI:2147870
210297
Rat
RGD:1590569
680591
Dog
leucine rich repeats and calponin homology domain containing 2
VGNC:42758
492078
Horse
leucine rich repeats and calponin homology domain containing 2
VGNC:19745
100053980
Species
Name
OMA
EggNOG
Inparanoid
Macaque
leucine rich repeats and calponin homology domain containing 2
Mouse
Rat
Dog
leucine rich repeats and calponin homology domain containing 2
Horse
leucine rich repeats and calponin homology domain containing 2
Publication Statistics
PubMed Score 0.43
PubMed score by year
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Related Publications
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PMID
Year
Title