You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

Protein Summary
Description
Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311191
  • ENSP00000308493
  • ENSG00000136141
  • ENST00000389797
  • ENSP00000374447
  • ENST00000389798
  • ENSP00000374448

Symbol
  • CHDC1
  • KIAA1016
  • NP81
  • CHDC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.97
transcription factor binding site profile
0.89
kinase perturbation
0.84
histone modification site profile
0.66
cell line
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.06   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.06   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
DOCK6
Tbio
Novelty:  0.01111596
p_int:  1
Score:  0.345
Data Source:  BioPlex,STRINGDB
DOCK8
Tbio
Novelty:  0.0067047
p_int:  0.999999997
p_ni:  2e-9
p_wrong:  2e-9
Score:  0.932
Data Source:  BioPlex,STRINGDB
LRCH4
Tbio
Novelty:  0.10751018
p_int:  0.999999963
p_ni:  3.7e-8
Data Source:  BioPlex
LRCH2
Tdark
Novelty:  1.90908316
p_int:  0.999999946
p_ni:  3.6e-8
p_wrong:  1.9e-8
Data Source:  BioPlex
LRCH3
Tdark
Novelty:  1.02650989
p_int:  0.999999676
p_ni:  2e-9
p_wrong:  3.23e-7
Score:  0.878
Data Source:  BioPlex,STRINGDB
DOCK7
Tbio
Novelty:  0.03425586
p_int:  0.999999657
p_ni:  3.43e-7
Score:  0.525
Data Source:  BioPlex,STRINGDB
SUGT1
Tbio
Novelty:  0.1042721
p_int:  0.981794933
p_ni:  0.018205068
Data Source:  BioPlex
CERS6
Tbio
Family:  TF
Novelty:  0.01956925
p_int:  0.963271444
p_ni:  0.036718163
p_wrong:  0.000010393
Data Source:  BioPlex
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.946515664
p_ni:  0.053484334
p_wrong:  3e-9
Data Source:  BioPlex
TMEM131L
Tbio
Novelty:  0.60395527
p_int:  0.935939721
p_ni:  0.064060279
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
95.7
electrocardiography
1
1
2
77.9
optic disc size measurement
1
1
1
67.1
systolic blood pressure
1
1
1
59.9
platelet count
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
95.7
electrocardiography
2
77.9
optic disc size measurement
1
67.1
systolic blood pressure
1
59.9
platelet count
1
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and calponin homology domain containing 1
VGNC:13126
452708
Macaque
leucine rich repeats and calponin homology domain containing 1
708778
Mouse
MGI:2443390
380916
Rat
RGD:1595678
502020
Dog
leucine rich repeats and calponin homology domain containing 1
VGNC:49754
476919
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and calponin homology domain containing 1
Macaque
leucine rich repeats and calponin homology domain containing 1
Mouse
Rat
Dog
leucine rich repeats and calponin homology domain containing 1
Publication Statistics
PubMed Score 12.06
PubMed score by year
PubTator Score 7.97
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title