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Tbio
LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

Protein Summary
Description
May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357115
  • ENSP00000349629
  • ENSG00000198589
  • ENST00000510413
  • ENSP00000421552

Symbol
  • BGL
  • CDC4L
  • LBA
  • BGL
  • LBA
  • CDC4L
  • CVID8
  • LAB300
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.98
protein domain
0.97
transcription factor perturbation
0.96
interacting protein
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1032.81   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1032.81   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
TMEM126A
Tbio
Novelty:  0.11759225
p_int:  0.999999249
p_ni:  7.51e-7
Data Source:  BioPlex
NCR3LG1
Tbio
Novelty:  0.02681936
p_int:  0.999864035
p_ni:  0.000135925
p_wrong:  4e-8
Data Source:  BioPlex
PVR
Tbio
Novelty:  0.00215811
p_int:  0.999217997
p_ni:  0.000781916
p_wrong:  8.8e-8
Data Source:  BioPlex
INSYN2
Tdark
Novelty:  2.55244594
p_int:  0.998932603
p_ni:  0.001067211
p_wrong:  1.86e-7
Data Source:  BioPlex
CYP2J2
Tchem
Novelty:  0.00534181
p_int:  0.998352227
p_ni:  0.001647773
Data Source:  BioPlex
RD3
Tbio
Novelty:  0.00651981
p_int:  0.997762101
p_ni:  0.002237899
Score:  0.199
Data Source:  BioPlex,STRINGDB
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.996443035
p_ni:  0.003556924
p_wrong:  4.1e-8
Score:  0.168
Data Source:  BioPlex,STRINGDB
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.994460487
p_ni:  0.005539513
Data Source:  BioPlex
SLC27A4
Tchem
Family:  Transporter
Novelty:  0.0143834
p_int:  0.99221591
p_ni:  0.00778409
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.987565451
p_ni:  0.012434549
Score:  0.564
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
78.1
alkaline phosphatase measurement
2
1
1
8.7
77.7
neutrophil count
2
1
2
70.5
leukocyte count
1
1
1
59
systolic blood pressure
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
78.1
alkaline phosphatase measurement
1
8.7
77.7
neutrophil count
2
70.5
leukocyte count
1
59
systolic blood pressure
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LPS responsive beige-like anchor protein
VGNC:10383
471319
Mouse
MGI:1933162
80877
Rat
RGD:1311428
361975
Dog
LPS responsive beige-like anchor protein
VGNC:42757
475463
Horse
LPS responsive beige-like anchor protein
VGNC:19743
102149621
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LPS responsive beige-like anchor protein
Mouse
Rat
Dog
LPS responsive beige-like anchor protein
Horse
LPS responsive beige-like anchor protein
Publication Statistics
PubMed Score 1032.81
PubMed score by year
PubTator Score 212.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title