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Tchem
LPL
Lipoprotein lipase

Protein Summary
Description
The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL) (PubMed:27578112). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity). LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311322
  • ENSP00000309757
  • ENSG00000175445
  • ENST00000650287
  • ENSP00000497642

Symbol
  • LIPD
  • LIPD
  • HDLCQ11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
metabolite
1
gene perturbation
0.98
PubMedID
0.94
trait
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1060.07   (req: < 5)
Gene RIFs: 406   (req: <= 3)
Antibodies: 485   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1060.07   (req: >= 5)
Gene RIFs: 406   (req: > 3)
Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (308)
GPIHBP1
Tbio
Novelty:  0.01241227
Score:  0.993
Data Source:  Reactome,STRINGDB
APOC2
Tbio
Novelty:  0.0015496
Score:  0.992
Data Source:  STRINGDB
ANGPTL4
Tbio
Novelty:  0.00237867
Score:  0.987
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.986
Data Source:  STRINGDB
APOC3
Tclin
Novelty:  0.0009635
Score:  0.985
Data Source:  STRINGDB
APOA5
Tbio
Novelty:  0.00232222
Score:  0.982
Data Source:  STRINGDB
ANGPTL3
Tclin
Novelty:  0.00595539
Score:  0.981
Data Source:  STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.98
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.98
Data Source:  STRINGDB
FABP4
Tchem
Novelty:  0.00107707
Score:  0.98
Data Source:  STRINGDB
Pathways (35)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Chylomicron remodeling
Reactome
Developmental Biology
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Chylomicron remodeling
Developmental Biology
G alpha (i) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
45
66
145
9.6
100
high density lipoprotein cholesterol measurement
33
57
119
3
100
apolipoprotein A 1 measurement
2
19
19
99.9
sleep duration
4
17
27
99.6
metabolic syndrome
4
7
7
99.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
145
9.6
100
high density lipoprotein cholesterol measurement
119
3
100
apolipoprotein A 1 measurement
19
99.9
sleep duration
27
99.6
metabolic syndrome
7
99.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipoprotein lipase
VGNC:854
464031
Macaque
lipoprotein lipase
712887
Mouse
MGI:96820
16956
Rat
RGD:3017
24539
Dog
lipoprotein lipase
VGNC:42754
403626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipoprotein lipase
Macaque
lipoprotein lipase
Mouse
Rat
Dog
lipoprotein lipase
Publication Statistics
PubMed Score 1060.07
PubMed score by year
PubTator Score 2814.94
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title