Tbio LPCAT3 Lysophospholipid acyltransferase 5

Protein Summary

Description

Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Uniprot Accession IDs

• Q6P1A2
• B2RDH0
• B7Z3N3
• Q7KZS1
• Q92980
• Q9BW40
• LPLAT 5

Gene Name

• LPCAT3

Ensembl ID

• ENST00000261407
• ENSP00000261407
• ENSG00000111684

Symbol

• MBOAT5
• OACT5
• C3F
• LPCAT
• LPSAT
• OACT5
• nessy
• MBOAT5
• LPLAT 5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
histone modification site profile	0.81
metabolite	0.81
transcription factor binding site profile	0.74
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Lysophospholipid Acyltransferase 5

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Lysophospholipid Acyltransferase 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.17   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 58   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.17   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0