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Tbio
LPCAT3
Lysophospholipid acyltransferase 5

Protein Summary
Description
Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261407
  • ENSP00000261407
  • ENSG00000111684

Symbol
  • MBOAT5
  • OACT5
  • C3F
  • LPCAT
  • LPSAT
  • OACT5
  • nessy
  • MBOAT5
  • LPLAT 5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
histone modification site profile
0.81
metabolite
0.81
transcription factor binding site profile
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.41   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.41   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.998395788
p_ni:  0.001604211
p_wrong:  1e-9
Score:  0.266
Data Source:  BioPlex,STRINGDB
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.997624847
p_ni:  0.002373546
p_wrong:  0.000001607
Data Source:  BioPlex
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.996678683
p_ni:  0.003321164
p_wrong:  1.53e-7
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.995790824
p_ni:  0.004209175
p_wrong:  1e-9
Data Source:  BioPlex
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.991605389
p_ni:  0.008394608
p_wrong:  3e-9
Data Source:  BioPlex
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.985244096
p_ni:  0.014755898
p_wrong:  6e-9
Data Source:  BioPlex
ATP5PF
Tbio
Family:  Enzyme
Novelty:  0.00585408
p_int:  0.984470824
p_ni:  0.015528005
p_wrong:  0.000001171
Data Source:  BioPlex
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.973321096
p_ni:  0.026678894
p_wrong:  1e-8
Data Source:  BioPlex
SLC5A8
Tchem
Family:  Transporter
Novelty:  0.00892277
p_int:  0.969174122
p_ni:  0.03078842
p_wrong:  0.000037458
Data Source:  BioPlex
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
p_int:  0.969076423
p_ni:  0.030863547
p_wrong:  0.00006003
Data Source:  BioPlex
Pathways (14)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PS
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PS
Glycerophospholipid biosynthesis
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
oleic acid measurement
2
3
3
95.7
docosapentaenoic acid measurement
1
2
2
92.8
fatty acid measurement
1
2
2
92.8
linolenic acid measurement
1
2
2
92.8
arachidonic acid measurement
1
2
2
92.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
oleic acid measurement
3
95.7
docosapentaenoic acid measurement
2
92.8
fatty acid measurement
2
92.8
linolenic acid measurement
2
92.8
arachidonic acid measurement
2
92.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidylcholine acyltransferase 3
VGNC:5458
451807
Macaque
lysophosphatidylcholine acyltransferase 3
714639
Mouse
MGI:1315211
14792
Rat
RGD:1310223
362434
Dog
lysophosphatidylcholine acyltransferase 3
VGNC:54322
486715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidylcholine acyltransferase 3
Macaque
lysophosphatidylcholine acyltransferase 3
Mouse
Rat
Dog
lysophosphatidylcholine acyltransferase 3
Publication Statistics
PubMed Score 210.41
PubMed score by year
PubTator Score 91.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title