Tbio LPCAT2 Lysophosphatidylcholine acyltransferase 2

Protein Summary

Description

Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q7L5N7
• A3KBM1
• Q6MZJ6
• Q9NX23
• LPC acyltransferase 2

Gene Name

• LPCAT2

Ensembl ID

• ENST00000262134
• ENSP00000262134
• ENSG00000087253

Symbol

• AGPAT11
• AYTL1
• AYTL1
• AGPAT11
• LysoPAFAT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
transcription factor perturbation	0.84
microRNA	0.81
metabolite	0.8
interacting protein	0.79

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Lysophosphatidylcholine Acyltransferase 2

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Lysophosphatidylcholine Acyltransferase 2

Protein / Calcium-binding Protein / Annexin / Lysophosphatidylcholine Acyltransferase 2

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Lysophosphatidylcholine Acyltransferase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.13   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.13   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (113)

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1 – 10 of 113

• See Interactions on String-DB

PPP4R3B

Tbio

Family:  Enzyme

Novelty:  0.0185504

p_int:  0.998105525

p_ni:  0.001894048

p_wrong:  4.27e-7

Data Source:  BioPlex

EMB

Tbio

Novelty:  0.00135577

p_int:  0.997380445

p_ni:  0.002512242

p_wrong:  0.000107313

Data Source:  BioPlex

SURF1

Tbio

Novelty:  0.00717605

p_int:  0.996872014

p_ni:  0.003113568

p_wrong:  0.000014418

Data Source:  BioPlex

SLC39A10

Tbio

Family:  Transporter

Novelty:  0.03527885

p_int:  0.995436499

p_ni:  0.004563501

Data Source:  BioPlex

ADGRL1

Tbio

Family:  GPCR

Novelty:  0.00957739

p_int:  0.984717813

p_ni:  0.015282168

p_wrong:  1.9e-8

Data Source:  BioPlex

HERC3

Tbio

Family:  Enzyme

Novelty:  0.05231675

p_int:  0.981839469

p_ni:  0.01816053

p_wrong:  1e-9

Data Source:  BioPlex

SLC39A6

Tbio

Family:  Transporter

Novelty:  0.0144314

p_int:  0.972842848

p_ni:  0.027157152

Data Source:  BioPlex

VMP1

Tbio

Novelty:  0.00997613

p_int:  0.923811057

p_ni:  0.075852487

p_wrong:  0.000336456

Data Source:  BioPlex

NDUFAF1

Tclin

Novelty:  0.05630549

p_int:  0.91142184

p_ni:  0.08857816

Data Source:  BioPlex

METTL9

Tdark

Family:  Enzyme

Novelty:  0.20589257

p_int:  0.906989985

p_ni:  0.093010015

Data Source:  BioPlex

Nearest Tclin Targets (2)

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Upstream (1)

Downstream (1)

1 – 1 of 1

ACHE

Tclin

Family:  Enzyme

KEGG Distance:  5

Common Pathways:  1

1: Glycerophospholipid metabolism

Pathways (9)

Reactome (5)

KEGG (3)

UniProt (1)

Acyl chain remodelling of PC (R-HSA-1482788)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Acyl chain remodelling of PC	27 targets	R-HSA-1482788
Reactome	Glycerophospholipid biosynthesis	129 targets	R-HSA-1483206
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Phospholipid metabolism	211 targets	R-HSA-1483257

Name	Explore in Pharos	Explore in Source
Acyl chain remodelling of PC	27 targets	R-HSA-1482788
Glycerophospholipid biosynthesis	129 targets	R-HSA-1483206
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Phospholipid metabolism	211 targets	R-HSA-1483257

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (5)

Components (6)

Processes (3)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
1-acylglycerophosphocholine O-acyltransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
1-alkylglycerophosphocholine O-acetyltransferase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
1-acylglycerol-3-phosphate O-acyltransferase activity	Traceable Author Statement (TAS)	Reactome
2-acylglycerol-3-phosphate O-acyltransferase activity	Traceable Author Statement (TAS)	Reactome
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (4)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	2	2		88.7
birth weight	EFO_0004344	1	1	1		40.7
age-related hearing impairment	EFO_0005782	1	1	0	5.7	24.5
hormone measurement	EFO_0004730	1	1	1		14.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		88.7
birth weight	EFO_0004344	1		40.7
age-related hearing impairment	EFO_0005782	0	5.7	24.5
hormone measurement	EFO_0004730	1		14.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acyltransferase
Alternative splicing
Calcium
Complete proteome
Endoplasmic reticulum
Golgi apparatus
Lipid biosynthesis
Lipid droplet
Lipid metabolism
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
age-related hearing impairment
birth weight
heel bone mineral density
hormone measurement

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	lysophosphatidylcholine acyltransferase 2	VGNC:5833	454095
Macaque	lysophosphatidylcholine acyltransferase 2		698605
Mouse	lysophosphatidylcholine acyltransferase 2	MGI:3606214	270084
Rat	lysophosphatidylcholine acyltransferase 2	RGD:2325051	100359680
Dog	lysophosphatidylcholine acyltransferase 2	VGNC:42749	611330

Species	Name	OMA	EggNOG	Inparanoid
Chimp	lysophosphatidylcholine acyltransferase 2
Macaque	lysophosphatidylcholine acyltransferase 2
Mouse	lysophosphatidylcholine acyltransferase 2
Rat	lysophosphatidylcholine acyltransferase 2
Dog	lysophosphatidylcholine acyltransferase 2

Publication Statistics

PubMed Score 42.13

PubMed score by year

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PubTator Score 10.06

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (9)

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PMID	Year	Title