Tbio LPCAT2 Lysophosphatidylcholine acyltransferase 2

Protein Summary

Description

Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q7L5N7
• A3KBM1
• Q6MZJ6
• Q9NX23
• LPC acyltransferase 2

Gene Name

• LPCAT2

Ensembl ID

• ENST00000262134
• ENSP00000262134
• ENSG00000087253

Symbol

• AGPAT11
• AYTL1
• AYTL1
• AGPAT11
• LysoPAFAT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
transcription factor perturbation	0.84
microRNA	0.81
metabolite	0.8
interacting protein	0.79

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Lysophosphatidylcholine Acyltransferase 2

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Lysophosphatidylcholine Acyltransferase 2

Protein / Calcium-binding Protein / Annexin / Lysophosphatidylcholine Acyltransferase 2

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Lysophosphatidylcholine Acyltransferase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.69   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.69   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0