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Tbio
LPCAT1
Lysophosphatidylcholine acyltransferase 1

Protein Summary
Description
Possesses both acyltransferase and acetyltransferase activities (PubMed:16864775, PubMed:21498505). Activity is calcium-independent (By similarity). Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (PubMed:21498505). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16704971). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16864775). Involved in the regulation of lipid droplet number and size (PubMed:25491198). This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283415
  • ENSP00000283415
  • ENSG00000153395
  • ENST00000475622
  • ENSP00000423472

Symbol
  • AYTL2
  • PFAAP3
  • AYTL2
  • lpcat
  • AGPAT9
  • PFAAP3
  • AGPAT10
  • LPCAT-1
  • lysoPAFAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor perturbation
0.88
metabolite
0.81
interacting protein
0.8
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.59   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.59   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
p_int:  0.96240508
p_ni:  0.037594919
Score:  0.365
Data Source:  BioPlex,STRINGDB
MSTO1
Tbio
Novelty:  0.05914188
p_int:  0.954829155
p_ni:  0.045170162
p_wrong:  6.83e-7
Score:  0.222
Data Source:  BioPlex,STRINGDB
MTR
Tbio
Family:  Enzyme
Novelty:  0.0006987
p_int:  0.77719851
p_ni:  0.22280149
Score:  0.332
Data Source:  BioPlex,STRINGDB
DIP2A
Tbio
Novelty:  0.09357918
p_int:  0.766310096
p_ni:  0.233689903
Score:  0.27
Data Source:  BioPlex,STRINGDB
CHPT1
Tbio
Family:  Enzyme
Novelty:  0.02875977
Score:  0.971
Data Source:  STRINGDB
LPCAT3
Tbio
Family:  Enzyme
Novelty:  0.00485213
Score:  0.964
Data Source:  STRINGDB
STARD10
Tbio
Novelty:  0.09791035
Score:  0.944
Data Source:  Reactome,STRINGDB
CEPT1
Tchem
Family:  Enzyme
Novelty:  0.01816476
Score:  0.934
Data Source:  STRINGDB
CRLS1
Tbio
Family:  Enzyme
Novelty:  0.08214782
Score:  0.933
Data Source:  STRINGDB
PEMT
Tbio
Family:  Enzyme
Novelty:  0.00786252
Score:  0.926
Data Source:  STRINGDB
Pathways (15)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PG
Reactome
Glycerophospholipid biosynthesis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PG
Glycerophospholipid biosynthesis
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
1
1
1
56
sleep duration
1
1
1
50.6
CC16 measurement
1
1
1
17.8
body mass index
1
1
1
12.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
1
56
sleep duration
1
50.6
CC16 measurement
1
17.8
body mass index
1
12.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidylcholine acyltransferase 1
VGNC:4073
461698
Macaque
lysophosphatidylcholine acyltransferase 1
710144
Mouse
MGI:2384812
210992
Rat
RGD:1311599
361467
Dog
lysophosphatidylcholine acyltransferase 1
VGNC:42748
488066
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidylcholine acyltransferase 1
Macaque
lysophosphatidylcholine acyltransferase 1
Mouse
Rat
Dog
lysophosphatidylcholine acyltransferase 1
Publication Statistics
PubMed Score 90.59
PubMed score by year
PubTator Score 52.60
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title