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Tchem
LPAR6
Lysophosphatidic acid receptor 6

Protein Summary
Description
Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345941
  • ENSP00000344353
  • ENSG00000139679
  • ENST00000378434
  • ENSP00000367691
  • ENST00000620633
  • ENSP00000482660

Symbol
  • P2RY5
  • LAH3
  • P2Y5
  • ARWH1
  • HYPT8
  • P2RY5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
PubMedID
0.86
transcription factor perturbation
0.8
small molecule perturbation
0.69
tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.17   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.17   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (9)
Protein-Protein Interactions (225)
DMD
Tclin
Novelty:  0.00025661
p_int:  0.998391692
p_ni:  0.001593147
p_wrong:  0.000015161
Score:  0.161
Data Source:  BioPlex,STRINGDB
FAM126A
Tbio
Novelty:  0.0250547
p_int:  0.995413311
p_ni:  0.002861509
p_wrong:  0.001725179
Score:  0.159
Data Source:  BioPlex,STRINGDB
PKP2
Tbio
Novelty:  0.00493803
p_int:  0.99084065
p_ni:  0.00915935
Data Source:  BioPlex
LMBRD2
Tdark
Novelty:  0.60495132
p_int:  0.979694017
p_ni:  0.020289809
p_wrong:  0.000016174
Data Source:  BioPlex
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.970597174
p_ni:  0.029393316
p_wrong:  0.00000951
Data Source:  BioPlex
SFXN5
Tdark
Novelty:  0.30379915
p_int:  0.968158836
p_ni:  0.031054958
p_wrong:  0.000786206
Data Source:  BioPlex
MTX3
Tdark
Novelty:  0.06082176
p_int:  0.967025903
p_ni:  0.032974097
Data Source:  BioPlex
ATL3
Tbio
Novelty:  0.05295598
p_int:  0.944079768
p_ni:  0.055920066
p_wrong:  1.66e-7
Data Source:  BioPlex
RAB32
Tbio
Family:  Enzyme
Novelty:  0.02514559
p_int:  0.943676917
p_ni:  0.054385453
p_wrong:  0.00193763
Data Source:  BioPlex
STX10
Tbio
Novelty:  0.05193552
p_int:  0.942707654
p_ni:  0.057221856
p_wrong:  0.00007049
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (16)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Nucleotide-like (purinergic) receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Nucleotide-like (purinergic) receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
61.4
birth weight
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
61.4
birth weight
1
21.5
Find similar targets by:
IDG Resources
Genetic Construct
LPAR6-Tango
image for LPAR6-Tango
Details:
  • Vector:  addgene66422
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • LPAR6-Tango
Order Genetic Construct from:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidic acid receptor 6
VGNC:13125
741241
Macaque
lysophosphatidic acid receptor 6
705081
Mouse
MGI:1914418
67168
Rat
RGD:1595950
691774
Dog
lysophosphatidic acid receptor 6
VGNC:42747
100856069
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysophosphatidic acid receptor 6
Macaque
lysophosphatidic acid receptor 6
Mouse
Rat
Dog
lysophosphatidic acid receptor 6
Publication Statistics
PubMed Score 58.17
PubMed score by year
PubTator Score 56.62
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title