LPAR5
Lysophosphatidic acid receptor 5
Protein Summary
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
- ENST00000329858
- ENSP00000327875
- ENSG00000184574
- ENST00000431922
- ENSP00000393098
- GPR92
- GPR93
- LPA5
- GPR92
- GPR93
- KPG_010
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.61 | ||
microRNA | 0.58 | ||
transcription factor | 0.53 | ||
cell type or tissue | 0.45 | ||
metabolite | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.51 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 181 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.51 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 181 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 81
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0