LPAR4
Lysophosphatidic acid receptor 4
Protein Summary
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA. This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]
- ENST00000435339
- ENSP00000408205
- ENSG00000147145
- ENST00000614823
- ENSP00000478261
- GPR23
- LPA4
- P2RY9
- LPA4
- P2Y9
- GPR23
- P2RY9
- P2Y5-LIKE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.63 | ||
microRNA | 0.6 | ||
cell type or tissue | 0.58 | ||
small molecule perturbation | 0.57 | ||
disease perturbation | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.62 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 268 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.62 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 268 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0