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Tchem
LPAR4
Lysophosphatidic acid receptor 4

Protein Summary
Description
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA. This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000435339
  • ENSP00000408205
  • ENSG00000147145
  • ENST00000614823
  • ENSP00000478261

Symbol
  • GPR23
  • LPA4
  • P2RY9
  • LPA4
  • P2Y9
  • GPR23
  • P2RY9
  • P2Y5-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.63
microRNA
0.6
cell type or tissue
0.58
small molecule perturbation
0.57
disease perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.62   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.62   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (16)
Protein-Protein Interactions (217)
SLC25A35
Tdark
Family:  Transporter
Novelty:  1.19834062
p_int:  0.999924289
p_ni:  0.000075658
p_wrong:  5.3e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
ACAD10
Tchem
Family:  Enzyme
Novelty:  0.09858243
p_int:  0.999502142
p_ni:  0.000497858
Data Source:  BioPlex
ATL3
Tbio
Novelty:  0.05295598
p_int:  0.998749039
p_ni:  0.001250961
Data Source:  BioPlex
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
p_int:  0.998722317
p_ni:  0.001277683
Data Source:  BioPlex
ARHGEF40
Tdark
Novelty:  0.3458097
p_int:  0.998564057
p_ni:  0.001435938
p_wrong:  5e-9
Score:  0.351
Data Source:  BioPlex,STRINGDB
CAV1
Tbio
Novelty:  0.00035244
p_int:  0.995577988
p_ni:  0.004419506
p_wrong:  0.000002506
Data Source:  BioPlex
TAMM41
Tbio
Family:  Enzyme
Novelty:  0.06004824
p_int:  0.992942585
p_ni:  0.006886427
p_wrong:  0.000170988
Data Source:  BioPlex
SPG7
Tbio
Family:  Enzyme
Novelty:  0.00463357
p_int:  0.992807012
p_ni:  0.007192987
Data Source:  BioPlex
EFR3A
Tbio
Novelty:  0.17687362
p_int:  0.989145941
p_ni:  0.010854058
Data Source:  BioPlex
PPTC7
Tbio
Family:  Enzyme
Novelty:  0.36770849
p_int:  0.988073632
p_ni:  0.01190732
p_wrong:  0.000019048
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (20)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Nucleotide-like (purinergic) receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Nucleotide-like (purinergic) receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
lysophosphatidic acid receptor 4
707170
Mouse
MGI:1925384
78134
Rat
RGD:1563686
302378
Dog
lysophosphatidic acid receptor 4
VGNC:42745
491978
Horse
lysophosphatidic acid receptor 4
VGNC:19730
100071749
Species
Name
OMA
EggNOG
Inparanoid
Macaque
lysophosphatidic acid receptor 4
Mouse
Rat
Dog
lysophosphatidic acid receptor 4
Horse
lysophosphatidic acid receptor 4
Publication Statistics
PubMed Score 48.62
PubMed score by year
PubTator Score 27.29
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title