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Tchem
LPAR1
Lysophosphatidic acid receptor 1

Protein Summary
Description
Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (Pub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358883
  • ENSP00000351755
  • ENSG00000198121
  • ENST00000374430
  • ENSP00000363552
  • ENST00000374431
  • ENSP00000363553

Symbol
  • EDG2
  • LPA1
  • EDG2
  • LPA1
  • VZG1
  • GPR26
  • edg-2
  • vzg-1
  • Gpcr26
  • Mrec1.3
  • rec.1.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
biological process
0.96
kinase perturbation
0.88
PubMedID
0.88
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.2   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 396.2   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 141
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0