Protein Summary
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]
- ENST00000316300
- ENSP00000321334
- ENSG00000198670
- ENST00000447678
- ENSP00000395608
- LP
- AK38
- APOA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.95 | ||
trait | 0.86 | ||
disease | 0.75 | ||
phenotype | 0.67 | ||
cellular component | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1770.2 (req: < 5)
Gene RIFs: 281 (req: <= 3)
Antibodies: 294 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1770.2 (req: >= 5)
Gene RIFs: 281 (req: > 3)
Antibodies: 294 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (143)
Nearest Tclin Targets
Pathways (7)
Reactome (4)
KEGG (1)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | LDL remodeling | ||||
Reactome | Plasma lipoprotein assembly, remodeling, and clearance | ||||
Reactome | Plasma lipoprotein remodeling | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
LDL remodeling | ||||
Plasma lipoprotein assembly, remodeling, and clearance | ||||
Plasma lipoprotein remodeling | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (5)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (45)
Items per page:
1 – 5 of 45
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lipoprotein A measurement | 5 | 50 | 8 | 8.2 | 100 | ||||
apolipoprotein A 1 measurement | 4 | 25 | 4 | 9.1 | 99.9 | ||||
low density lipoprotein cholesterol measurement | 10 | 11 | 20 | 8.1 | 99.8 | ||||
10 | 12 | 11 | 1.4 | 99.6 | |||||
total cholesterol measurement | 5 | 10 | 15 | 8.7 | 99.6 | ||||
Items per page:
1 – 5 of 45
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lipoprotein A measurement | 8 | 8.2 | 100 | ||||
apolipoprotein A 1 measurement | 4 | 9.1 | 99.9 | ||||
low density lipoprotein cholesterol measurement | 20 | 8.1 | 99.8 | ||||
11 | 1.4 | 99.6 | |||||
total cholesterol measurement | 15 | 8.7 | 99.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lipoprotein(a) | VGNC:9969 | 463116 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lipoprotein(a) | |||||
Publication Statistics
PubMed Score 1770.20
PubMed score by year
PubTator Score 3122.28
PubTator score by year
Related Publications
Text Mined References (346)
GeneRif Annotations (281)
Items per page:
0 of 0
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