You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LPA
Apolipoprotein(a)

Protein Summary
Description
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316300
  • ENSP00000321334
  • ENSG00000198670
  • ENST00000447678
  • ENSP00000395608

Symbol
  • LP
  • AK38
  • APOA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.95
trait
0.86
disease
0.75
phenotype
0.67
cellular component
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1770.2   (req: < 5)
Gene RIFs: 281   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1770.2   (req: >= 5)
Gene RIFs: 281   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
APOB
Tchem
Novelty:  0.00008247
Score:  0.994
Data Source:  STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.985
Data Source:  STRINGDB
APOA2
Tbio
Novelty:  0.00117627
Score:  0.981
Data Source:  STRINGDB
LCAT
Tchem
Family:  Enzyme
Novelty:  0.00307544
Score:  0.969
Data Source:  STRINGDB
APOC3
Tclin
Novelty:  0.0009635
Score:  0.967
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.961
Data Source:  STRINGDB
CETP
Tchem
Novelty:  0.00051779
Score:  0.96
Data Source:  STRINGDB
APOM
Tbio
Novelty:  0.00505937
Score:  0.96
Data Source:  STRINGDB
APOA4
Tbio
Novelty:  0.00305835
Score:  0.953
Data Source:  STRINGDB
APOC2
Tbio
Novelty:  0.0015496
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
LDL remodeling (R-HSA-8964041)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
LDL remodeling
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
LDL remodeling
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (45)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein A measurement
5
50
8
8.2
100
apolipoprotein A 1 measurement
4
25
4
9.1
99.9
low density lipoprotein cholesterol measurement
10
11
20
8.1
99.8
10
12
11
1.4
99.6
total cholesterol measurement
5
10
15
8.7
99.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein A measurement
8
8.2
100
apolipoprotein A 1 measurement
4
9.1
99.9
low density lipoprotein cholesterol measurement
20
8.1
99.8
11
1.4
99.6
total cholesterol measurement
15
8.7
99.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipoprotein(a)
VGNC:9969
463116
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipoprotein(a)
Publication Statistics
PubMed Score 1770.20
PubMed score by year
PubTator Score 3122.28
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title