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Tbio
LOXL1
Lysyl oxidase homolog 1

Protein Summary
Description
Active on elastin and collagen substrates. This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261921
  • ENSP00000261921
  • ENSG00000129038

Symbol
  • LOXL
  • LOL
  • LOXL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
PubMedID
0.85
transcription factor perturbation
0.8
biological term
0.76
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.95   (req: < 5)
Gene RIFs: 126   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.95   (req: >= 5)
Gene RIFs: 126   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.999998972
p_ni:  9.95e-7
p_wrong:  3.3e-8
Score:  0.243
Data Source:  BioPlex,STRINGDB
CD160
Tbio
Novelty:  0.01511748
p_int:  0.999839851
p_ni:  0.000023567
p_wrong:  0.000136582
Data Source:  BioPlex
A2M
Tbio
Novelty:  0.00070446
p_int:  0.998001153
p_ni:  0.000001899
p_wrong:  0.001996948
Score:  0.361
Data Source:  BioPlex,STRINGDB
FBLN5
Tbio
Novelty:  0.00599598
Score:  0.989
Data Source:  Reactome,STRINGDB
ELN
Tbio
Novelty:  0.00026801
Score:  0.985
Data Source:  Reactome,STRINGDB
MFAP2
Tbio
Novelty:  0.01599653
Score:  0.956
Data Source:  Reactome,STRINGDB
BMP1
Tchem
Novelty:  0.00299518
Score:  0.95
Data Source:  Reactome,STRINGDB
PCOLCE
Tbio
Family:  Enzyme
Novelty:  0.02012457
Score:  0.939
Data Source:  STRINGDB
LOXL2
Tchem
Family:  Enzyme
Novelty:  0.00599536
Score:  0.936
Data Source:  STRINGDB
LOX
Tchem
Family:  Enzyme
Novelty:  0.000273
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen formation
Reactome
Crosslinking of collagen fibrils
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen formation
Crosslinking of collagen fibrils
Elastic fibre formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
5
0
9.9
99.1
body height
4
3
4
92.5
appendicular lean mass
4
2
4
91.7
BMI-adjusted waist circumference
7
8
23
89
BMI-adjusted hip circumference
2
8
10
85.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
9.9
99.1
body height
4
92.5
appendicular lean mass
4
91.7
BMI-adjusted waist circumference
23
89
BMI-adjusted hip circumference
10
85.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysyl oxidase like 1
VGNC:6450
453735
Macaque
lysyl oxidase like 1 [Source:HGNC Symbol;Acc:HGNC:6665]
Mouse
MGI:106096
16949
Rat
RGD:1308752
315714
Dog
lysyl oxidase like 1
VGNC:49917
100686150
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysyl oxidase like 1
Macaque
lysyl oxidase like 1 [Source:HGNC Symbol;Acc:HGNC:6665]
Mouse
Rat
Dog
lysyl oxidase like 1
Publication Statistics
PubMed Score 248.95
PubMed score by year
PubTator Score 206.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title