Protein Summary
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
- ENST00000231004
- ENSP00000231004
- ENSG00000113083
- ENST00000639739
- ENSP00000492324
- AAT10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
PubMedID | 0.93 | ||
biological term | 0.84 | ||
disease | 0.82 | ||
small molecule perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3687.68 (req: < 5)
Gene RIFs: 148 (req: <= 3)
Antibodies: 720 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3687.68 (req: >= 5)
Gene RIFs: 148 (req: > 3)
Antibodies: 720 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (1)
Protein-Protein Interactions (228)
PDE7A
Family: Enzyme
Novelty: 0.00872596
p_int: 0.999985195
p_ni: 0.000014708
p_wrong: 9.7e-8
Data Source: BioPlex
PDP1
Family: Enzyme
Novelty: 0.00442352
p_int: 0.999965734
p_ni: 0.000034266
Data Source: BioPlex
N4BP2L2
Novelty: 0.24527466
p_int: 0.976493928
p_ni: 0.023502931
p_wrong: 0.000003141
Data Source: BioPlex
ARNT
Family: TF
Novelty: 0.00183071
p_int: 0.956853332
p_ni: 0.043145795
p_wrong: 8.73e-7
Score: 0.261
Data Source: BioPlex,STRINGDB
ALG13
Family: Enzyme
Novelty: 0.04054611
p_int: 0.856112896
p_ni: 0.143887104
Data Source: BioPlex
HSPA5
Novelty: 0.00043424
p_int: 0.825766301
p_ni: 0.174233699
Score: 0.174
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (5)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Collagen formation | ||||
Reactome | Crosslinking of collagen fibrils | ||||
Reactome | Elastic fibre formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Collagen formation | ||||
Crosslinking of collagen fibrils | ||||
Elastic fibre formation | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (2)
Components (5)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 1 | 1 | 74.8 | |||||
intraocular pressure measurement | 1 | 2 | 2 | 63.6 | |||||
2 | 2 | 1 | 1.1 | 45.6 | |||||
1 | 1 | 1 | 31.2 | ||||||
central corneal thickness | 1 | 1 | 0 | 1.7 | 12.7 | ||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 74.8 | |||||
intraocular pressure measurement | 2 | 63.6 | |||||
1 | 1.1 | 45.6 | |||||
1 | 31.2 | ||||||
central corneal thickness | 0 | 1.7 | 12.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lysyl oxidase | VGNC:4072 | 471614 | |||||
Mouse | MGI:96817 | 16948 | ||||||
Rat | RGD:3015 | 24914 | ||||||
Dog | lysyl oxidase | VGNC:42737 | 481478 | |||||
Cow | lysyl oxidase | VGNC:30951 | 280841 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lysyl oxidase | |||||
Mouse | ||||||
Rat | ||||||
Dog | lysyl oxidase | |||||
Cow | lysyl oxidase | |||||
Publication Statistics
PubMed Score 3687.68
PubMed score by year
PubTator Score 622.56
PubTator score by year
Related Publications
Text Mined References (182)
GeneRif Annotations (148)
Items per page:
0 of 0
PMID | Year | Title |
|---|