Protein Summary
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
- ENST00000231004
- ENSP00000231004
- ENSG00000113083
- ENST00000639739
- ENSP00000492324
- AAT10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.97 | ||
PubMedID | 0.93 | ||
biological term | 0.84 | ||
disease | 0.82 | ||
small molecule perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3687.68 (req: < 5)
Gene RIFs: 148 (req: <= 3)
Antibodies: 720 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3687.68 (req: >= 5)
Gene RIFs: 148 (req: > 3)
Antibodies: 720 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (1)
Active Ligands (1)
Protein-Protein Interactions (228)
PDE7A
Family: Enzyme
Novelty: 0.00872596
p_int: 0.999985195
p_ni: 0.000014708
p_wrong: 9.7e-8
Data Source: BioPlex
PDP1
Family: Enzyme
Novelty: 0.00442352
p_int: 0.999965734
p_ni: 0.000034266
Data Source: BioPlex
N4BP2L2
Novelty: 0.24527466
p_int: 0.976493928
p_ni: 0.023502931
p_wrong: 0.000003141
Data Source: BioPlex
ARNT
Family: TF
Novelty: 0.00183071
p_int: 0.956853332
p_ni: 0.043145795
p_wrong: 8.73e-7
Score: 0.261
Data Source: BioPlex,STRINGDB
ALG13
Family: Enzyme
Novelty: 0.04054611
p_int: 0.856112896
p_ni: 0.143887104
Data Source: BioPlex
HSPA5
Novelty: 0.00043424
p_int: 0.825766301
p_ni: 0.174233699
Score: 0.174
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (5)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Collagen formation | ||||
Reactome | Crosslinking of collagen fibrils | ||||
Reactome | Elastic fibre formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Collagen formation | ||||
Crosslinking of collagen fibrils | ||||
Elastic fibre formation | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (2)
Components (5)
Processes (11)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 1 | 1 | 74.8 | |||||
intraocular pressure measurement | 1 | 2 | 2 | 63.6 | |||||
2 | 2 | 1 | 1.1 | 45.6 | |||||
1 | 1 | 1 | 31.2 | ||||||
central corneal thickness | 1 | 1 | 0 | 1.7 | 12.7 | ||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 74.8 | |||||
intraocular pressure measurement | 2 | 63.6 | |||||
1 | 1.1 | 45.6 | |||||
1 | 31.2 | ||||||
central corneal thickness | 0 | 1.7 | 12.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | lysyl oxidase | VGNC:4072 | 471614 | |||||
Mouse | MGI:96817 | 16948 | ||||||
Rat | RGD:3015 | 24914 | ||||||
Dog | lysyl oxidase | VGNC:42737 | 481478 | |||||
Cow | lysyl oxidase | VGNC:30951 | 280841 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | lysyl oxidase | |||||
Mouse | ||||||
Rat | ||||||
Dog | lysyl oxidase | |||||
Cow | lysyl oxidase | |||||
Publication Statistics
PubMed Score 3687.68
PubMed score by year
PubTator Score 622.56
PubTator score by year
Related Publications
Text Mined References (182)
GeneRif Annotations (148)
Items per page:
0 of 0
PMID | Year | Title |
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