Protein Summary
Major keratinocyte cell envelope protein. This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. [provided by RefSeq, Jul 2008]
- ENST00000368742
- ENSP00000357731
- ENSG00000203782
- LRN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 0.94 | ||
cell type or tissue | 0.7 | ||
PubMedID | 0.66 | ||
tissue sample | 0.53 | ||
cellular component | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 275.89 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 275.89 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (114)
DTL
Novelty: 0.01659105
p_int: 0.99682599
p_ni: 0.00317116
p_wrong: 0.000002849
Data Source: BioPlex
AAAS
Novelty: 0.00830233
p_int: 0.983774221
p_ni: 0.016224842
p_wrong: 9.37e-7
Data Source: BioPlex
B3GALNT1
Family: Enzyme
Novelty: 0.01235828
p_int: 0.972346378
p_ni: 0.02725486
p_wrong: 0.000398762
Score: 0.217
Data Source: BioPlex,STRINGDB
NDUFS5
Family: Enzyme
Novelty: 0.13274675
p_int: 0.971438423
p_ni: 0.028560242
p_wrong: 0.000001335
Data Source: BioPlex
BEX5
Novelty: 0.2964824
p_int: 0.88506087
p_ni: 0.113819738
p_wrong: 0.001119392
Data Source: BioPlex
ZSCAN12
Family: TF
Novelty: 0.33578207
p_int: 0.798072693
p_ni: 0.076004833
p_wrong: 0.125922474
Data Source: BioPlex
PI4KA
Family: Kinase
Novelty: 0.01701469
p_int: 0.791508447
p_ni: 0.137317306
p_wrong: 0.071174247
Score: 0.181
Data Source: BioPlex,STRINGDB
ZDHHC23
Family: Enzyme
Novelty: 0.18700442
p_int: 0.780645425
p_ni: 0.093307689
p_wrong: 0.126046886
Score: 0.252
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (4)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
matrix metalloproteinase 8 measurement | 1 | 1 | 1 | 14.2 | |||||
vitamin D measurement | 1 | 1 | 1 | 13.8 | |||||
balding measurement | 1 | 1 | 1 | 11.5 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
matrix metalloproteinase 8 measurement | 1 | 14.2 | |||||
vitamin D measurement | 1 | 13.8 | |||||
balding measurement | 1 | 11.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Cow | loricrin | 505154 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Cow | loricrin | |||||
Publication Statistics
PubMed Score 275.89
PubMed score by year
PubTator Score 211.94
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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