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Tbio
LOR
Loricrin

Protein Summary
Description
Major keratinocyte cell envelope protein. This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368742
  • ENSP00000357731
  • ENSG00000203782

Symbol
  • LRN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.94
cell type or tissue
0.7
PubMedID
0.66
tissue sample
0.53
cellular component
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.89   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.89   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
DTL
Tbio
Novelty:  0.01659105
p_int:  0.99682599
p_ni:  0.00317116
p_wrong:  0.000002849
Data Source:  BioPlex
AAAS
Tbio
Novelty:  0.00830233
p_int:  0.983774221
p_ni:  0.016224842
p_wrong:  9.37e-7
Data Source:  BioPlex
B3GALNT1
Tbio
Family:  Enzyme
Novelty:  0.01235828
p_int:  0.972346378
p_ni:  0.02725486
p_wrong:  0.000398762
Score:  0.217
Data Source:  BioPlex,STRINGDB
NDUFS5
Tclin
Family:  Enzyme
Novelty:  0.13274675
p_int:  0.971438423
p_ni:  0.028560242
p_wrong:  0.000001335
Data Source:  BioPlex
BEX5
Tdark
Novelty:  0.2964824
p_int:  0.88506087
p_ni:  0.113819738
p_wrong:  0.001119392
Data Source:  BioPlex
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.798072693
p_ni:  0.076004833
p_wrong:  0.125922474
Data Source:  BioPlex
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.791508447
p_ni:  0.137317306
p_wrong:  0.071174247
Score:  0.181
Data Source:  BioPlex,STRINGDB
ZDHHC23
Tbio
Family:  Enzyme
Novelty:  0.18700442
p_int:  0.780645425
p_ni:  0.093307689
p_wrong:  0.126046886
Score:  0.252
Data Source:  BioPlex,STRINGDB
IVL
Tbio
Novelty:  0.00147892
Score:  0.993
Data Source:  STRINGDB
FLG
Tbio
Novelty:  0.00072986
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 8 measurement
1
1
1
14.2
vitamin D measurement
1
1
1
13.8
balding measurement
1
1
1
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 8 measurement
1
14.2
vitamin D measurement
1
13.8
balding measurement
1
11.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Cow
loricrin
505154
Species
Name
OMA
EggNOG
Inparanoid
Cow
loricrin
Publication Statistics
PubMed Score 275.89
PubMed score by year
PubTator Score 211.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title