Tbio LOR Loricrin

Protein Summary

Description

Major keratinocyte cell envelope protein. This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P23490
• Q5T869
• Q5XKF8

Gene Name

• LOR

Ensembl ID

• ENST00000368742
• ENSP00000357731
• ENSG00000203782

Symbol

• LRN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.94
cell type or tissue	0.7
PubMedID	0.66
tissue sample	0.53
cellular component	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.89   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 71   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.89   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (114)

Explore Interacting Targets

1 – 10 of 114

• See Interactions on String-DB

DTL

Tbio

Novelty:  0.01659105

p_int:  0.99682599

p_ni:  0.00317116

p_wrong:  0.000002849

Data Source:  BioPlex

AAAS

Tbio

Novelty:  0.00830233

p_int:  0.983774221

p_ni:  0.016224842

p_wrong:  9.37e-7

Data Source:  BioPlex

B3GALNT1

Tbio

Family:  Enzyme

Novelty:  0.01235828

p_int:  0.972346378

p_ni:  0.02725486

p_wrong:  0.000398762

Score:  0.217

Data Source:  BioPlex,STRINGDB

NDUFS5

Tclin

Family:  Enzyme

Novelty:  0.13274675

p_int:  0.971438423

p_ni:  0.028560242

p_wrong:  0.000001335

Data Source:  BioPlex

BEX5

Tdark

Novelty:  0.2964824

p_int:  0.88506087

p_ni:  0.113819738

p_wrong:  0.001119392

Data Source:  BioPlex

ZSCAN12

Tdark

Family:  TF

Novelty:  0.33578207

p_int:  0.798072693

p_ni:  0.076004833

p_wrong:  0.125922474

Data Source:  BioPlex

PI4KA

Tchem

Family:  Kinase

Novelty:  0.01701469

p_int:  0.791508447

p_ni:  0.137317306

p_wrong:  0.071174247

Score:  0.181

Data Source:  BioPlex,STRINGDB

ZDHHC23

Tbio

Family:  Enzyme

Novelty:  0.18700442

p_int:  0.780645425

p_ni:  0.093307689

p_wrong:  0.126046886

Score:  0.252

Data Source:  BioPlex,STRINGDB

IVL

Tbio

Novelty:  0.00147892

Score:  0.993

Data Source:  STRINGDB

FLG

Tbio

Novelty:  0.00072986

Score:  0.992

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Developmental Biology (R-HSA-1266738)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Formation of the cornified envelope	75 targets	R-HSA-6809371
Reactome	Keratinization	217 targets	R-HSA-6805567

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Formation of the cornified envelope	75 targets	R-HSA-6809371
Keratinization	217 targets	R-HSA-6805567

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (4)

Components (4)

Processes (3)

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1 – 4 of 4

GO Term	Evidence	Assigned by
protein binding, bridging	Inferred from Direct Assay (IDA)	UniProtKB
structural constituent of epidermis	Inferred from Direct Assay (IDA)	CAFA
structural molecule activity	Inferred from Direct Assay (IDA)	UniProtKB
structural constituent of cytoskeleton	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
matrix metalloproteinase 8 measurement	EFO_0008466	1	1	1		14.2
vitamin D measurement	EFO_0004631	1	1	1		13.8
balding measurement	EFO_0007825	1	1	1		11.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
matrix metalloproteinase 8 measurement	EFO_0008466	1		14.2
vitamin D measurement	EFO_0004631	1		13.8
balding measurement	EFO_0007825	1		11.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Ichthyosis
Isopeptide bond
Keratinization
Nucleus
Palmoplantar keratoderma
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
matrix metalloproteinase 8 measurement
vitamin D measurement

MGI Phenotype Find Similar Targets

No Header	No Header
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging
nervous system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (1)

1 – 1 of 1

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Cow	loricrin		505154

Species	Name	OMA	EggNOG	Inparanoid
Cow	loricrin

Publication Statistics

PubMed Score 275.89

PubMed score by year

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PubTator Score 211.94

PubTator score by year

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Related Publications

Text Mined References (41)

GeneRif Annotations (20)

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10

0 of 0

PMID	Year	Title