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Tdark
LONRF2
LON peptidase N-terminal domain and RING finger protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393437
  • ENSP00000377086
  • ENSG00000170500
  • ENST00000409647
  • ENSP00000386823

Symbol
  • RNF192
  • RNF192
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cellular component
0.75
microRNA
0.73
molecular function
0.63
PubMedID
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.74   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.74   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
SNX24
Tdark
Novelty:  0.20838126
p_int:  0.999999417
p_ni:  5.8e-8
p_wrong:  5.25e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
HSPB8
Tbio
Novelty:  0.00298618
p_int:  0.999993841
p_ni:  0.000006159
Score:  0.221
Data Source:  BioPlex,STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.999988204
p_ni:  0.000011795
p_wrong:  1e-9
Data Source:  BioPlex
C9orf40
Tdark
Novelty:  2.72763898
p_int:  0.999874326
p_ni:  0.000122943
p_wrong:  0.000002731
Data Source:  BioPlex
ARL15
Tbio
Family:  Enzyme
Novelty:  0.09327102
p_int:  0.999788149
p_ni:  0.000211851
p_wrong:  1e-9
Score:  0.31
Data Source:  BioPlex,STRINGDB
LONRF1
Tdark
Family:  Enzyme
Novelty:  0.55361076
p_int:  0.999769969
p_ni:  0.000230031
Score:  0.211
Data Source:  BioPlex,STRINGDB
XRCC4
Tbio
Novelty:  0.00305644
p_int:  0.999662199
p_ni:  0.0003378
Score:  0.519
Data Source:  BioPlex,STRINGDB
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
p_int:  0.998880328
p_ni:  0.001039811
p_wrong:  0.000079861
Data Source:  BioPlex
DPYSL5
Tbio
Family:  Enzyme
Novelty:  0.0052536
p_int:  0.998115835
p_ni:  0.001855099
p_wrong:  0.000029066
Score:  0.265
Data Source:  BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.981993584
p_ni:  0.011259455
p_wrong:  0.00674696
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
8
7
8
4.6
98.2
mathematical ability
4
4
5
95.6
household income
2
17
18
93.3
intelligence
8
18
11
6.3
91.5
body mass index
2
2
2
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
8
4.6
98.2
mathematical ability
5
95.6
household income
18
93.3
intelligence
11
6.3
91.5
body mass index
2
84.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LON peptidase N-terminal domain and ring finger 2
VGNC:10740
470451
Macaque
LON peptidase N-terminal domain and ring finger 2
709835
Mouse
MGI:1920209
381338
Rat
RGD:1562137
301361
Dog
LON peptidase N-terminal domain and ring finger 2
VGNC:42735
481336
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LON peptidase N-terminal domain and ring finger 2
Macaque
LON peptidase N-terminal domain and ring finger 2
Mouse
Rat
Dog
LON peptidase N-terminal domain and ring finger 2
Publication Statistics
PubMed Score 0.74
PubMed score by year
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Related Publications
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PMID
Year
Title