You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LNPK
Endoplasmic reticulum junction formation protein lunapark

Protein Summary
Description
Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb and central nervous system development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272748
  • ENSP00000272748
  • ENSG00000144320
  • ENST00000409660
  • ENSP00000386237
  • ENST00000544803
  • ENSP00000440905

Symbol
  • KIAA1715
  • LNP
  • Ul
  • LNP
  • LNP1
  • NEDEHCC
  • KIAA1715
  • ulnaless
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.33   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.33   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
p_int:  0.999935453
p_ni:  0.000064547
Score:  0.15
Data Source:  BioPlex,STRINGDB
SYNPR
Tbio
Novelty:  0.04046273
p_int:  0.999703645
p_ni:  0.000296355
Score:  0.519
Data Source:  BioPlex,STRINGDB
EDA
Tbio
Novelty:  0.00352464
p_int:  0.999463238
p_ni:  0.000536762
Score:  0.328
Data Source:  BioPlex,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.997478146
p_ni:  0.00252183
p_wrong:  2.4e-8
Data Source:  BioPlex
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.997375461
p_ni:  0.002624502
p_wrong:  3.7e-8
Data Source:  BioPlex
ZDHHC11
Tdark
Family:  Enzyme
Novelty:  0.35249931
p_int:  0.996982564
p_ni:  0.003017436
Data Source:  BioPlex
METTL9
Tdark
Family:  Enzyme
Novelty:  0.20589257
p_int:  0.99223665
p_ni:  0.007763328
p_wrong:  2.2e-8
Data Source:  BioPlex
VAC14
Tbio
Novelty:  0.02677738
p_int:  0.991354581
p_ni:  0.008645418
p_wrong:  1e-9
Data Source:  BioPlex
COG7
Tbio
Novelty:  0.07137701
p_int:  0.989320977
p_ni:  0.010679022
p_wrong:  1e-9
Data Source:  BioPlex
SLC34A2
Tchem
Family:  Transporter
Novelty:  0.00601743
p_int:  0.976417763
p_ni:  0.023582237
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
21.4
wellbeing measurement
2
2
2
21.1
digit length ratio
2
1
2
10.7
insomnia measurement
1
1
0
1.1
9.3
mathematical ability
1
1
1
8.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
21.4
wellbeing measurement
2
21.1
digit length ratio
2
10.7
insomnia measurement
0
1.1
9.3
mathematical ability
1
8.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lunapark, ER junction formation factor
VGNC:14150
459759
Macaque
lunapark, ER junction formation factor
703373
Mouse
MGI:1918115
69605
Rat
RGD:1312042
362151
Dog
lunapark, ER junction formation factor
VGNC:42731
478809
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lunapark, ER junction formation factor
Macaque
lunapark, ER junction formation factor
Mouse
Rat
Dog
lunapark, ER junction formation factor
Publication Statistics
PubMed Score 22.33
PubMed score by year
PubTator Score 11.12
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title