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Tchem
LNPEP
Leucyl-cystinyl aminopeptidase

Protein Summary
Description
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by Re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231368
  • ENSP00000231368
  • ENSG00000113441
  • ENST00000395770
  • ENSP00000379117

Symbol
  • OTASE
  • CAP
  • IRAP
  • PLAP
  • P-LAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor binding site profile
0.98
transcription factor perturbation
0.91
histone modification site profile
0.87
small molecule perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.48   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.48   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (70)
CHEMBL4101200
Rendered image for CHEMBL4101200
compound 17 [PMID: 23916253]
Rendered image for compound 17 [PMID: 23916253]
CHEMBL3416733
Rendered image for CHEMBL3416733
CHEMBL4097268
Rendered image for CHEMBL4097268
CHEMBL4095882
Rendered image for CHEMBL4095882
CHEMBL4099107
Rendered image for CHEMBL4099107
CHEMBL4077855
Rendered image for CHEMBL4077855
CHEMBL4099693
Rendered image for CHEMBL4099693
CHEMBL4081682
Rendered image for CHEMBL4081682
CHEMBL4081073
Rendered image for CHEMBL4081073
Protein-Protein Interactions (184)
BTNL8
Tdark
Novelty:  0.40339869
p_int:  0.999638298
p_ni:  0.000361702
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999512865
p_ni:  0.000487135
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.999282041
p_ni:  0.000717959
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.998618103
p_ni:  0.001381897
Data Source:  BioPlex
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  0.99396913
p_ni:  0.00603087
Score:  0.152
Data Source:  BioPlex,STRINGDB
TMEM267
Tdark
Novelty:  3.50142721
p_int:  0.989572715
p_ni:  0.010427285
Score:  0.187
Data Source:  BioPlex,STRINGDB
SCGB1D4
Tdark
Novelty:  0.15597658
p_int:  0.988581365
p_ni:  0.011418635
Data Source:  BioPlex
CYP2J2
Tchem
Novelty:  0.00534181
p_int:  0.987780078
p_ni:  0.012219922
Data Source:  BioPlex
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
p_int:  0.982495365
p_ni:  0.017504635
Data Source:  BioPlex
SIAE
Tbio
Family:  Enzyme
Novelty:  0.01138067
p_int:  0.979049072
p_ni:  0.020950928
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Endosomal/Vacuolar pathway
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Endosomal/Vacuolar pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
77.8
neutrophil count
2
2
2
73.4
1
1
0
1.2
67.9
2
1
0
1.1
63.4
aspartate aminotransferase measurement
1
1
0
6.8
51.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
77.8
neutrophil count
2
73.4
0
1.2
67.9
0
1.1
63.4
aspartate aminotransferase measurement
0
6.8
51.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucyl and cystinyl aminopeptidase
VGNC:13540
461960
Macaque
leucyl and cystinyl aminopeptidase
703949
Mouse
MGI:2387123
240028
Dog
leucyl and cystinyl aminopeptidase
VGNC:42730
488896
Horse
leucyl and cystinyl aminopeptidase
VGNC:19717
100073222
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucyl and cystinyl aminopeptidase
Macaque
leucyl and cystinyl aminopeptidase
Mouse
Dog
leucyl and cystinyl aminopeptidase
Horse
leucyl and cystinyl aminopeptidase
Publication Statistics
PubMed Score 424.48
PubMed score by year
PubTator Score 495.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title