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Tbio
LMX1B
LIM homeobox transcription factor 1-beta

Protein Summary
Description
Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355497
  • ENSP00000347684
  • ENSG00000136944
  • ENST00000373474
  • ENSP00000362573
  • ENST00000526117
  • ENSP00000436930

Symbol
  • NPS1
  • LMX1.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
pathway
0.73
cell type or tissue
0.64
transcription factor binding site profile
0.62
microRNA
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.17   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.17   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (135)
SSBP3
Tbio
Novelty:  0.01955714
p_int:  1
Score:  0.83
Data Source:  BioPlex,STRINGDB
SSBP2
Tbio
Novelty:  0.06546999
p_int:  1
Score:  0.768
Data Source:  BioPlex,STRINGDB
SSBP4
Tdark
Novelty:  0.27365687
p_int:  1
Score:  0.709
Data Source:  BioPlex,STRINGDB
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
p_int:  0.999999661
p_ni:  3.39e-7
Score:  0.898
Data Source:  BioPlex,STRINGDB
MEIS2
Tbio
Family:  TF
Novelty:  0.01393828
p_int:  0.999999582
p_ni:  4.17e-7
p_wrong:  1e-9
Score:  0.893
Data Source:  BioPlex,STRINGDB
LDB1
Tbio
Novelty:  0.01110112
p_int:  0.999999549
p_ni:  4.51e-7
Score:  0.938
Data Source:  BioPlex,STRINGDB
PKNOX2
Tbio
Family:  TF
Novelty:  0.02053794
p_int:  0.999999274
p_ni:  4.73e-7
p_wrong:  2.52e-7
Score:  0.354
Data Source:  BioPlex,STRINGDB
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
p_int:  0.999994251
p_ni:  0.000005749
Score:  0.771
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.999974113
p_ni:  0.000025882
p_wrong:  5e-9
Score:  0.153
Data Source:  BioPlex,STRINGDB
PBX3
Tbio
Family:  TF
Novelty:  0.01516183
p_int:  0.9999544
p_ni:  0.0000456
Score:  0.862
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Primary Focal Segmental Glomerulosclerosis FSGS
WikiPathways
Dopaminergic Neurogenesis
Name
Explore in Pharos
Explore in Source
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Primary Focal Segmental Glomerulosclerosis FSGS
Dopaminergic Neurogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
7
10
95.7
3
4
0
1.2
94.8
calcium measurement
2
4
4
90.8
body mass index
8
5
10
83.6
corneal topography
2
1
2
76.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
10
95.7
0
1.2
94.8
calcium measurement
4
90.8
body mass index
10
83.6
corneal topography
2
76.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
LIM homeobox transcription factor 1 beta
701912
Mouse
MGI:1100513
16917
Rat
RGD:620843
114501
Dog
LIM homeobox transcription factor 1 beta
VGNC:42729
403499
Xenopus
LIM homeobox transcription factor 1, beta, gene 1
XB-GENE-494750
100495130
Species
Name
OMA
EggNOG
Inparanoid
Macaque
LIM homeobox transcription factor 1 beta
Mouse
Rat
Dog
LIM homeobox transcription factor 1 beta
Xenopus
LIM homeobox transcription factor 1, beta, gene 1
Publication Statistics
PubMed Score 269.17
PubMed score by year
PubTator Score 114.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title