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Tbio
LMO2
Rhombotin-2

Protein Summary
Description
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257818
  • ENSP00000257818
  • ENSG00000135363
  • ENST00000395833
  • ENSP00000379175
  • ENST00000411482
  • ENSP00000401967

Symbol
  • RBTN2
  • RBTNL1
  • RHOM2
  • TTG2
  • TTG2
  • LMO-2
  • RBTN2
  • RHOM2
  • RBTNL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
virus perturbation
0.99
molecular function
0.98
kinase perturbation
0.96
disease perturbation
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.53   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 682   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.53   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 682   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0