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Tbio
LMNB2
Lamin-B2

Protein Summary
Description
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325327
  • ENSP00000327054
  • ENSG00000176619

Symbol
  • LMN2
  • EPM9
  • LMN2
  • LAMB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
kinase perturbation
0.91
transcription factor perturbation
0.84
co-expressed gene
0.72
cellular component
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.68   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.68   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (151)
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.961742586
p_ni:  0.038257414
Score:  0.337
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.925445083
p_ni:  0.074554917
Data Source:  BioPlex
ENTHD1
Tdark
Novelty:  5.29427978
p_int:  0.797916358
p_ni:  0.202083642
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.785911221
p_ni:  0.214088779
Data Source:  BioPlex
LMNA
Tbio
Novelty:  0.00046972
Score:  0.957
Data Source:  STRINGDB
CASP6
Tchem
Family:  Enzyme
Novelty:  0.00234346
Score:  0.95
Data Source:  STRINGDB
LMNB1
Tbio
Novelty:  0.00127348
Score:  0.949
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.925
Data Source:  STRINGDB
CASP2
Tchem
Family:  Enzyme
Novelty:  0.00189892
Score:  0.923
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
80.3
age-related hearing impairment
1
1
0
5.9
48.6
mathematical ability
1
1
1
19
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
80.3
age-related hearing impairment
0
5.9
48.6
mathematical ability
1
19
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
lamin B2
100426602
Mouse
MGI:96796
16907
Rat
RGD:1563803
299625
Dog
lamin B2
VGNC:42719
485070
Cow
lamin B2
VGNC:30931
516326
Species
Name
OMA
EggNOG
Inparanoid
Macaque
lamin B2
Mouse
Rat
Dog
lamin B2
Cow
lamin B2
Publication Statistics
PubMed Score 590.68
PubMed score by year
PubTator Score 74.70
PubTator score by year
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Related Publications
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PMID
Year
Title