Protein Summary
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
- ENST00000261366
- ENSP00000261366
- ENSG00000113368
- LMN2
- LMNB
- LMN
- ADLD
- LMN2
- LMNB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 0.98 | ||
transcription factor binding site profile | 0.95 | ||
hub protein | 0.92 | ||
interacting protein | 0.9 | ||
cellular component | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 931.37 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 695 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 931.37 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 695 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (271)
GNAI2
Novelty: 0.03014729
p_int: 0.79606921
p_ni: 0.20393079
Score: 0.31
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (127)
Reactome (32)
KEGG (1)
PathwayCommons (2)
WikiPathways (92)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Breakdown of the nuclear lamina | ||||
Reactome | Cell Cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Breakdown of the nuclear lamina | ||||
Cell Cycle | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (8)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
basophil percentage of leukocytes | 2 | 1 | 2 | 86.2 | |||||
basophil count | 4 | 1 | 4 | 76 | |||||
basophil percentage of granulocytes | 1 | 1 | 1 | 68.1 | |||||
blood protein measurement | 1 | 1 | 1 | 64.3 | |||||
serum metabolite measurement | 1 | 1 | 1 | 43.7 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
basophil percentage of leukocytes | 2 | 86.2 | |||||
basophil count | 4 | 76 | |||||
basophil percentage of granulocytes | 1 | 68.1 | |||||
blood protein measurement | 1 | 64.3 | |||||
serum metabolite measurement | 1 | 43.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lamin B1 | VGNC:4071 | 462035 | |||||
Macaque | lamin B1 | 703575 | ||||||
Mouse | MGI:96795 | 16906 | ||||||
Rat | RGD:620522 | 116685 | ||||||
Dog | lamin B1 | VGNC:42718 | 474663 | |||||
Publication Statistics
PubMed Score 931.37
PubMed score by year
PubTator Score 174.84
PubTator score by year
Related Publications
Text Mined References (102)
GeneRif Annotations (58)
Items per page:
0 of 0
PMID | Year | Title |
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