Protein Summary
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). Prelamin-A/C can accelerate smoot ...more
- ENST00000347559
- ENSP00000292304
- ENSG00000160789
- ENST00000368299
- ENSP00000357282
- ENST00000368300
- ENSP00000357283
- ENST00000368301
- ENSP00000357284
- ENST00000448611
- ENSP00000395597
- ENST00000473598
- ENSP00000421821
- LMN1
- FPL
- IDC
- LFP
- CDDC
- EMD2
- FPLD
- HGPS
- LDP1
- LMN1
- LMNC
- MADA
- PRO1
- CDCD1
- CMD1A
- FPLD2
- LMNL1
- CMT2B1
- LGMD1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
interacting protein | 1 | ||
ligand (protein) perturbation | 1 | ||
transcription factor perturbation | 1 | ||
biological process | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2740.51 (req: < 5)
Gene RIFs: 495 (req: <= 3)
Antibodies: 1465 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2740.51 (req: >= 5)
Gene RIFs: 495 (req: > 3)
Antibodies: 1465 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (316)
Nearest Tclin Targets
Pathways (46)
Reactome (28)
KEGG (4)
PathwayCommons (2)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Breakdown of the nuclear lamina | ||||
Reactome | Cell Cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Breakdown of the nuclear lamina | ||||
Cell Cycle | ||||
Viral Interactions (0)
Gene Ontology Terms (34)
Functions (2)
Components (10)
Processes (22)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (31)
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mosaic loss of chromosome Y measurement | 3 | 2 | 3 | 97.3 | |||||
body mass index | 5 | 2 | 5 | 90.2 | |||||
leukocyte count | 4 | 2 | 4 | 80.4 | |||||
Parkinson disease | 3 | 2 | 2 | 1.5 | 78.4 | ||||
serum urea measurement | 1 | 4 | 4 | 78.2 | |||||
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mosaic loss of chromosome Y measurement | 3 | 97.3 | |||||
body mass index | 5 | 90.2 | |||||
leukocyte count | 4 | 80.4 | |||||
Parkinson disease | 2 | 1.5 | 78.4 | ||||
serum urea measurement | 4 | 78.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lamin A/C | VGNC:11515 | 457385 | |||||
Macaque | lamin A/C | 719414 | ||||||
Mouse | MGI:96794 | 16905 | ||||||
Rat | RGD:620456 | 60374 | ||||||
Dog | lamin A/C | VGNC:42717 | 480124 | |||||
Publication Statistics
PubMed Score 2740.51
PubMed score by year
PubTator Score 1568.26
PubTator score by year
Related Publications
Text Mined References (619)
GeneRif Annotations (495)
Items per page:
0 of 0
PMID | Year | Title |
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