Tdark LMLN Leishmanolysin-like peptidase

Protein Summary

Description

Metalloprotease. This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q96KR4
• B3LDG9
• B3LDH0
• C9J796
• F8WB28
• Q96KR5

Gene Name

• LMLN

Ensembl ID

• ENST00000330198
• ENSP00000328829
• ENSG00000185621
• ENST00000420910
• ENSP00000410926
• ENST00000482695
• ENSP00000418324

Symbol

• INV
• MSP
• GP63
• IX14
• LMNL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.72
transcription factor binding site profile	0.69
transcription factor perturbation	0.68
microRNA	0.65
tissue sample	0.65

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / Leishmanolysin-like Peptidase

Protein / Cell Adhesion Molecule / Leishmanolysin-like Peptidase

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Leishmanolysin-like Peptidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.53   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.53   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (26)

Explore Interacting Targets

1 – 10 of 26

• See Interactions on String-DB

LCN6

Tbio

Novelty:  0.11406686

p_int:  0.999716651

p_ni:  0.000218061

p_wrong:  0.000065288

Data Source:  BioPlex

RLN1

Tbio

Novelty:  0.03992636

p_int:  0.999277394

p_ni:  0.000619623

p_wrong:  0.000102983

Data Source:  BioPlex

ADAM18

Tdark

Family:  Enzyme

Novelty:  0.22622379

p_int:  0.999172788

p_ni:  0.00050678

p_wrong:  0.000320432

Data Source:  BioPlex

TMEM25

Tdark

Novelty:  0.35505784

p_int:  0.977635459

p_ni:  0.000540948

p_wrong:  0.021823593

Data Source:  BioPlex

ISLR

Tbio

Novelty:  0.02936208

p_int:  0.935693625

p_ni:  0.008194232

p_wrong:  0.056112143

Score:  0.157

Data Source:  BioPlex,STRINGDB

TAZ

Tbio

Novelty:  0.00372301

p_int:  0.915913923

p_ni:  0.003524139

p_wrong:  0.080561938

Data Source:  BioPlex

F9

Tchem

Family:  Enzyme

Novelty:  0.00032127

p_int:  0.905841603

p_ni:  0.000927181

p_wrong:  0.093231215

Score:  0.183

Data Source:  BioPlex,STRINGDB

LYPD4

Tbio

Novelty:  0.00381728

p_int:  0.884814677

p_ni:  0.000915079

p_wrong:  0.114270244

Data Source:  BioPlex

PON2

Tbio

Family:  Enzyme

Novelty:  0.00414855

p_int:  0.86914304

p_ni:  0.001205351

p_wrong:  0.129651608

Data Source:  BioPlex

CCT7

Tbio

Novelty:  0.02247038

Score:  0.65

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (3)

Components (5)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
peptidase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metalloendopeptidase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell cycle
Cell division
Complete proteome
Cytoplasm
Hydrolase
Lipid droplet
Metal-binding
Metalloprotease
Mitosis

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	leishmanolysin like peptidase	VGNC:14240	460976
Macaque	leishmanolysin like peptidase		722196
Mouse	leishmanolysin-like (metallopeptidase M8 family)	MGI:2444736	239833
Rat	leishmanolysin like peptidase	RGD:1311465	363795
Dog	leishmanolysin like peptidase	VGNC:42716	609201

Species	Name	OMA	EggNOG	Inparanoid
Chimp	leishmanolysin like peptidase
Macaque	leishmanolysin like peptidase
Mouse	leishmanolysin-like (metallopeptidase M8 family)
Rat	leishmanolysin like peptidase
Dog	leishmanolysin like peptidase

Publication Statistics

PubMed Score 364.53

PubMed score by year

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PubTator Score 148.72

PubTator score by year

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Related Publications

Text Mined References (5)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title