You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
LMLN
Leishmanolysin-like peptidase

Protein Summary
Description
Metalloprotease. This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330198
  • ENSP00000328829
  • ENSG00000185621
  • ENST00000420910
  • ENSP00000410926
  • ENST00000482695
  • ENSP00000418324

Symbol
  • INV
  • MSP
  • GP63
  • IX14
  • LMNL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
transcription factor binding site profile
0.69
transcription factor perturbation
0.68
microRNA
0.65
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.53   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.53   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
LCN6
Tbio
Novelty:  0.11406686
p_int:  0.999716651
p_ni:  0.000218061
p_wrong:  0.000065288
Data Source:  BioPlex
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.999277394
p_ni:  0.000619623
p_wrong:  0.000102983
Data Source:  BioPlex
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.999172788
p_ni:  0.00050678
p_wrong:  0.000320432
Data Source:  BioPlex
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.977635459
p_ni:  0.000540948
p_wrong:  0.021823593
Data Source:  BioPlex
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.935693625
p_ni:  0.008194232
p_wrong:  0.056112143
Score:  0.157
Data Source:  BioPlex,STRINGDB
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.915913923
p_ni:  0.003524139
p_wrong:  0.080561938
Data Source:  BioPlex
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
p_int:  0.905841603
p_ni:  0.000927181
p_wrong:  0.093231215
Score:  0.183
Data Source:  BioPlex,STRINGDB
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.884814677
p_ni:  0.000915079
p_wrong:  0.114270244
Data Source:  BioPlex
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.86914304
p_ni:  0.001205351
p_wrong:  0.129651608
Data Source:  BioPlex
CCT7
Tbio
Novelty:  0.02247038
Score:  0.65
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leishmanolysin like peptidase
VGNC:14240
460976
Macaque
leishmanolysin like peptidase
722196
Mouse
MGI:2444736
239833
Rat
RGD:1311465
363795
Dog
leishmanolysin like peptidase
VGNC:42716
609201
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leishmanolysin like peptidase
Macaque
leishmanolysin like peptidase
Mouse
Rat
Dog
leishmanolysin like peptidase
Publication Statistics
PubMed Score 364.53
PubMed score by year
PubTator Score 148.72
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title