Tbio LMF2 Lipase maturation factor 2

Protein Summary

Description

Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).

Uniprot Accession IDs

• Q9BU23
• A6NEZ0
• Q13392
• Q6ZNR2
• Q8WU74
• Q96C62

Gene Name

• LMF2

Ensembl ID

• ENST00000216080
• ENSP00000216080
• ENSG00000100258
• ENST00000474879
• ENSP00000424381

Symbol

• TMEM112B
• TMEM153
• TMEM153
• TMEM112B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
cell type or tissue	0.72
transcription factor perturbation	0.68
kinase perturbation	0.6
cell line	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 117   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0