Tbio LMCD1 LIM and cysteine-rich domains protein 1

Protein Summary

Description

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• Q9NZU5
• B4DG80

Gene Name

• LMCD1

Ensembl ID

• ENST00000157600
• ENSP00000157600
• ENSG00000071282
• ENST00000454244
• ENSP00000396515

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
kinase perturbation	0.91
PubMedID	0.87
virus perturbation	0.79
cell type or tissue	0.72

Protein Classes

PANTHER Classes

Protein / Structural Protein / Lim And Cysteine-rich Domains Protein 1

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Lim And Cysteine-rich Domains Protein 1

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Lim And Cysteine-rich Domains Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.02   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.02   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0