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Tbio
LMBR1
Limb region 1 protein homolog

Protein Summary
Description
Putative membrane receptor. This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353442
  • ENSP00000326604
  • ENSG00000105983

Symbol
  • C7orf2
  • DIF14
  • LSS
  • TPT
  • ZRS
  • ACHP
  • PPD2
  • THYP
  • DIF14
  • C7orf2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
histone modification site profile
0.85
virus perturbation
0.76
transcription factor perturbation
0.74
transcription factor
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.53   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.53   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.997399936
p_ni:  0.002600064
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.98724141
p_ni:  0.012758589
p_wrong:  1e-9
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.972169578
p_ni:  0.027829655
p_wrong:  7.68e-7
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.954951838
p_ni:  0.045048162
Data Source:  BioPlex
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.951188176
p_ni:  0.048807588
p_wrong:  0.000004236
Data Source:  BioPlex
KLRC4
Tbio
Novelty:  0.16922525
p_int:  0.938377377
p_ni:  0.061461507
p_wrong:  0.000161116
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.931893545
p_ni:  0.068106455
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.915462559
p_ni:  0.084489502
p_wrong:  0.000047939
Data Source:  BioPlex
LYPD6
Tbio
Novelty:  0.13867181
p_int:  0.906525048
p_ni:  0.092208196
p_wrong:  0.001266756
Data Source:  BioPlex
EDNRA
Tclin
Family:  GPCR
Novelty:  0.00045591
p_int:  0.902245521
p_ni:  0.096104913
p_wrong:  0.001649566
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
51.4
lymphocyte percentage of leukocytes
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
51.4
lymphocyte percentage of leukocytes
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
limb development membrane protein 1
VGNC:4415
739991
Macaque
limb development membrane protein 1
719766
Mouse
MGI:1861746
56873
Rat
RGD:1563910
362295
Dog
limb development membrane protein 1
VGNC:42710
482819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
limb development membrane protein 1
Macaque
limb development membrane protein 1
Mouse
Rat
Dog
limb development membrane protein 1
Publication Statistics
PubMed Score 178.53
PubMed score by year
PubTator Score 64.95
PubTator score by year
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Related Publications
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PMID
Year
Title