Tbio LLGL2 Lethal(2) giant larvae protein homolog 2

Protein Summary

Description

Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6P1M3
• Q14521
• Q9BR62

Gene Name

• LLGL2

Ensembl ID

• ENST00000167462
• ENSP00000167462
• ENSG00000073350
• ENST00000375227
• ENSP00000364375
• ENST00000392550
• ENSP00000376333
• ENST00000578363
• ENSP00000464603

Symbol

• HGL
• LGL2
• Hugl-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
histone modification site profile	0.79
PubMedID	0.71
transcription factor	0.7
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Lethal(2) Giant Larvae Protein Homolog 2

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Lethal(2) Giant Larvae Protein Homolog 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0