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Tbio
LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

Protein Summary
Description
Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429). May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005). Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339430
  • ENSP00000340118
  • ENSG00000189067
  • ENST00000381810
  • ENSP00000371231
  • ENST00000413364
  • ENSP00000397958
  • ENST00000570904
  • ENSP00000459138
  • ENST00000571688
  • ENSP00000459533
  • ENST00000574763
  • ENSP00000461813
  • ENST00000576036
  • ENSP00000461667
  • ENST00000620789
  • ENSP00000481589
  • ENST00000622633
  • ENSP00000483114

Symbol
  • PIG7
  • SIMPLE
  • PIG7
  • SIMPLE
  • TP53I7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
virus perturbation
1
biological process
0.85
kinase perturbation
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.93   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.93   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0