Protein Summary
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. The gene encodes a lipase that is highly expressed in granular keratinocytes in the epidermis, and plays a role in the differentiation of keratinocytes. Mutations in this gene are associated with lamellar ichthyosis type 4. [provided by RefSeq, Dec 2011]
- ENST00000404459
- ENSP00000383923
- ENSG00000204020
- LIPL4
- LI4
- ARCI8
- LIPL4
- bA186O14.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.68 | ||
protein domain | 0.58 | ||
tissue | 0.42 | ||
cell line | 0.38 | ||
biological term | 0.33 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 751.78 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 751.78 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (40)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lipase family member N | VGNC:7852 | 466144 | |||||
Macaque | lipase family member N | 693761 | ||||||
Mouse | MGI:1917416 | 70166 | ||||||
Rat | RGD:1560354 | 499345 | ||||||
Horse | lipase family member N | VGNC:19689 | 100071663 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lipase family member N | |||||
Macaque | lipase family member N | |||||
Mouse | ||||||
Rat | ||||||
Horse | lipase family member N | |||||
Publication Statistics
PubMed Score 751.78
PubMed score by year
PubTator Score 399.88
PubTator score by year
Related Publications
Text Mined References (3)
GeneRif Annotations (1)
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