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Tbio
LIPN
Lipase member N

Protein Summary
Description
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. The gene encodes a lipase that is highly expressed in granular keratinocytes in the epidermis, and plays a role in the differentiation of keratinocytes. Mutations in this gene are associated with lamellar ichthyosis type 4. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404459
  • ENSP00000383923
  • ENSG00000204020

Symbol
  • LIPL4
  • LI4
  • ARCI8
  • LIPL4
  • bA186O14.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
protein domain
0.58
tissue
0.42
cell line
0.38
biological term
0.33


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 751.78   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 751.78   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
PCSK5
Tchem
Family:  Enzyme
Novelty:  0.00070772
Score:  0.893
Data Source:  STRINGDB
CYP4F22
Tbio
Novelty:  0.01907586
Score:  0.878
Data Source:  STRINGDB
SP6
Tbio
Family:  TF
Novelty:  0.00201789
Score:  0.86
Data Source:  STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.836
Data Source:  STRINGDB
PNPLA1
Tbio
Family:  Enzyme
Novelty:  0.03127922
Score:  0.797
Data Source:  STRINGDB
ACRV1
Tbio
Novelty:  0.00291978
Score:  0.789
Data Source:  STRINGDB
SP9
Tdark
Family:  TF
Novelty:  0.00476397
Score:  0.789
Data Source:  STRINGDB
MARVELD1
Tbio
Novelty:  0.01687447
Score:  0.789
Data Source:  STRINGDB
NIPAL4
Tbio
Novelty:  0.05110099
Score:  0.78
Data Source:  STRINGDB
ALOXE3
Tbio
Family:  Enzyme
Novelty:  0.02560954
Score:  0.761
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipase family member N
VGNC:7852
466144
Macaque
lipase family member N
693761
Mouse
MGI:1917416
70166
Rat
RGD:1560354
499345
Horse
lipase family member N
VGNC:19689
100071663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipase family member N
Macaque
lipase family member N
Mouse
Rat
Horse
lipase family member N
Publication Statistics
PubMed Score 751.78
PubMed score by year
PubTator Score 399.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title