Tchem LIPE Hormone-sensitive lipase

Protein Summary

Description

In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q05469
• Q3LRT2
• Q6NSL7
• HSL

Gene Name

• LIPE

Ensembl ID

• ENST00000244289
• ENSP00000244289
• ENSG00000079435

Symbol

• HSL
• LHS
• AOMS4
• FPLD6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
kinase	0.85
gene perturbation	0.82
biological term	0.76
disease perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 457.01   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 435   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 457.01   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 435   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 284

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0