LIPC
Hepatic triacylglycerol lipase
Protein Summary
Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]
- ENST00000299022
- ENSP00000299022
- ENSG00000166035
- ENST00000356113
- ENSP00000348425
- HTGL
- HL
- HTGL
- LIPH
- HDLCQ12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 1 | ||
trait | 0.97 | ||
protein domain | 0.92 | ||
disease | 0.91 | ||
biological term | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 533.8 (req: < 5)
Gene RIFs: 173 (req: <= 3)
Antibodies: 340 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 533.8 (req: >= 5)
Gene RIFs: 173 (req: > 3)
Antibodies: 340 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 326
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1