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Tchem
LIPC
Hepatic triacylglycerol lipase

Protein Summary
Description
Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299022
  • ENSP00000299022
  • ENSG00000166035
  • ENST00000356113
  • ENSP00000348425

Symbol
  • HTGL
  • HL
  • HTGL
  • LIPH
  • HDLCQ12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
trait
0.97
protein domain
0.92
disease
0.91
biological term
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 533.8   (req: < 5)
Gene RIFs: 160   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 533.8   (req: >= 5)
Gene RIFs: 160   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 326
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1