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Tbio
LINS1
Protein Lines homolog 1

Protein Summary
Description
The Drosophila segment polarity gene lin encodes a protein, lines, which plays important roles in development of the epidermis and hindgut. This gene encodes a protein containing a lines-like domain. This gene is located on chromosome 15 and clustered with the gene encoding ankyrin repeat and SOCS box-containing protein 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314742
  • ENSP00000318423
  • ENSG00000140471
  • ENST00000561308
  • ENSP00000454200

Symbol
  • LINS
  • WINS1
  • LINS
  • MRT27
  • WINS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
BCAS2
Tbio
Novelty:  0.05425016
p_int:  0.999998789
p_ni:  4.9e-8
p_wrong:  0.000001162
Data Source:  BioPlex
PLRG1
Tbio
Novelty:  0.05163655
p_int:  0.999995365
p_ni:  6.7e-8
p_wrong:  0.000004568
Score:  0.416
Data Source:  BioPlex,STRINGDB
GINS1
Tbio
Novelty:  0.08722396
Score:  0.714
Data Source:  STRINGDB
ELOVL4
Tbio
Novelty:  0.00737822
Score:  0.663
Data Source:  STRINGDB
DAND5
Tbio
Novelty:  0.01490697
Score:  0.659
Data Source:  STRINGDB
ASB7
Tdark
Novelty:  0.21883348
Score:  0.645
Data Source:  STRINGDB
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
Score:  0.57
Data Source:  STRINGDB
SDCBP2
Tbio
Novelty:  0.10574487
Score:  0.569
Data Source:  STRINGDB
CYGB
Tbio
Novelty:  0.0005482
Score:  0.557
Data Source:  STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.552
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
HGNC
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
4
3
5
84.9
chronotype measurement
2
2
1
1
76.2
optic cup area measurement
3
3
3
57.6
cotinine glucuronidation measurement
1
1
1
17.8
chin morphology measurement
1
1
0
1.1
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
5
84.9
chronotype measurement
1
1
76.2
optic cup area measurement
3
57.6
cotinine glucuronidation measurement
1
17.8
chin morphology measurement
0
1.1
11.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lines homolog 1
VGNC:1925
453781
Macaque
lines homolog 1
693833
Mouse
MGI:1919885
72635
Rat
RGD:1308792
308704
Dog
lines homolog 1
VGNC:42692
607902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lines homolog 1
Macaque
lines homolog 1
Mouse
Rat
Dog
lines homolog 1
Publication Statistics
PubMed Score 261.00
PubMed score by year
PubTator Score 13.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title