Tbio LIN7C Protein lin-7 homolog C

Protein Summary

Description

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Uniprot Accession IDs

• Q9NUP9
• Lin-7C

Gene Name

• LIN7C

Ensembl ID

• ENST00000278193
• ENSP00000278193
• ENSG00000148943

Symbol

• MALS3
• VELI3
• MALS3
• VELI3
• LIN-7C
• MALS-3
• LIN-7-C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
transcription factor perturbation	0.98
histone modification site profile	0.91
kinase perturbation	0.91
microRNA	0.86

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Protein Lin-7 Homolog C

Protein / Cell Adhesion Molecule / Protein Lin-7 Homolog C

DTO Classes

Protein / Cell-cell Junction / Protein Lin-7 Homolog C

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (126)

Explore Interacting Targets

1 – 10 of 126

• See Interactions on String-DB

CASK

Tchem

Family:  Kinase

Novelty:  0.00856437

p_int:  1

Score:  0.995

Data Source:  BioPlex,Reactome,STRINGDB

MPP7

Tbio

Novelty:  1.59072481

p_int:  1

Score:  0.975

Data Source:  BioPlex,STRINGDB

MPP2

Tbio

Novelty:  0.0372293

p_int:  1

Score:  0.956

Data Source:  BioPlex,STRINGDB

MPP5

Tbio

Novelty:  0.01707773

p_int:  1

Score:  0.943

Data Source:  BioPlex,STRINGDB

MPDZ

Tbio

Novelty:  0.01656439

p_int:  0.999999999

p_ni:  1e-9

Score:  0.765

Data Source:  BioPlex,STRINGDB

PATJ

Tbio

Novelty:  0.01420008

p_int:  0.999999999

p_ni:  1e-9

Score:  0.755

Data Source:  BioPlex,STRINGDB

DLG1

Tbio

Novelty:  0.0050926

p_int:  0.999999995

p_ni:  5e-9

Score:  0.931

Data Source:  BioPlex,STRINGDB

MPP6

Tbio

Novelty:  0.08883057

p_int:  0.999999892

p_ni:  1.08e-7

Score:  0.972

Data Source:  BioPlex,STRINGDB

KIF26B

Tbio

Novelty:  0.08162244

p_int:  0.999999665

p_ni:  1.6e-8

p_wrong:  3.19e-7

Score:  0.295

Data Source:  BioPlex,STRINGDB

APBA1

Tbio

Novelty:  0.01126648

p_int:  0.999999629

p_ni:  2.1e-8

p_wrong:  3.5e-7

Score:  0.982

Data Source:  BioPlex,Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (9)

Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Reactome	Assembly and cell surface presentation of NMDA receptors	24 targets	R-HSA-9609736
Reactome	Dopamine Neurotransmitter Release Cycle	23 targets	R-HSA-212676
Reactome	Neurexins and neuroligins	60 targets	R-HSA-6794361
Reactome	Neuronal System	398 targets	R-HSA-112316

Name	Explore in Pharos	Explore in Source
Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Assembly and cell surface presentation of NMDA receptors	24 targets	R-HSA-9609736
Dopamine Neurotransmitter Release Cycle	23 targets	R-HSA-212676
Neurexins and neuroligins	60 targets	R-HSA-6794361
Neuronal System	398 targets	R-HSA-112316

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (4)

Components (12)

Processes (5)

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1 – 4 of 4

GO Term	Evidence	Assigned by
L27 domain binding	Inferred from Direct Assay (IDA)	UniProtKB
cytoskeletal protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein domain specific binding	Inferred from Physical Interaction (IPI)	BHF-UCL
PDZ domain binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (11)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	1	3	3		87.7
balding measurement	EFO_0007825	1	2	2		82.4
bone density	EFO_0003923	3	2	7		72.7
obesity	EFO_0001073	1	1	0	1.4	67.9
hair color	EFO_0003924	1	1	0	1.1	59

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3		87.7
balding measurement	EFO_0007825	2		82.4
bone density	EFO_0003923	7		72.7
obesity	EFO_0001073	0	1.4	67.9
hair color	EFO_0003924	0	1.1	59

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Cell junction
Cell membrane
Complete proteome
Direct protein sequencing
Exocytosis
Membrane
Postsynaptic cell membrane
Protein transport

GWAS Trait Find Similar Targets

No Header	No Header
Alopecia
balding measurement
bone density
feeling miserable measurement
hair color
heel bone mineral density
hematocrit
hip circumference
obesity
urinary albumin to creatinine ratio

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	lin-7 homolog C, crumbs cell polarity complex component	VGNC:7759	466475
Macaque	lin-7 homolog C, crumbs cell polarity complex component		698832
Mouse	lin-7 homolog C (C. elegans)	MGI:1330839	22343
Rat	lin-7 homolog C, crumbs cell polarity complex component	RGD:621164	60442
Horse	lin-7 homolog C, crumbs cell polarity complex component	VGNC:19680	100072314

Species	Name	OMA	EggNOG	Inparanoid
Chimp	lin-7 homolog C, crumbs cell polarity complex component
Macaque	lin-7 homolog C, crumbs cell polarity complex component
Mouse	lin-7 homolog C (C. elegans)
Rat	lin-7 homolog C, crumbs cell polarity complex component
Horse	lin-7 homolog C, crumbs cell polarity complex component

Publication Statistics

PubMed Score 13.89

PubMed score by year

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PubTator Score 7.06

PubTator score by year

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Related Publications

Text Mined References (24)

GeneRif Annotations (9)

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PMID	Year	Title