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Tbio
LIN7A
Protein lin-7 homolog A

Protein Summary
Description
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is req ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000552864
  • ENSP00000447488
  • ENSG00000111052

Symbol
  • MALS1
  • VELI1
  • LIN7
  • MALS1
  • VELI1
  • LIN-7A
  • MALS-1
  • TIP-33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
interacting protein
0.72
virus perturbation
0.72
cellular component
0.67
tissue sample
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.62   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.62   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
MPP2
Tbio
Novelty:  0.0372293
p_int:  0.999976893
p_ni:  0.000023107
Score:  0.946
Data Source:  BioPlex,STRINGDB
MPP5
Tbio
Novelty:  0.01707773
p_int:  0.996025044
p_ni:  0.003974956
Score:  0.896
Data Source:  BioPlex,STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
p_int:  0.994045364
p_ni:  0.005954604
p_wrong:  3.3e-8
Score:  0.818
Data Source:  BioPlex,STRINGDB
SLC20A1
Tbio
Family:  Transporter
Novelty:  0.01123373
p_int:  0.990128406
p_ni:  0.009871594
Score:  0.795
Data Source:  BioPlex,STRINGDB
NSUN2
Tbio
Family:  Enzyme
Novelty:  0.01546947
p_int:  0.85214799
p_ni:  0.147852009
Score:  0.241
Data Source:  BioPlex,STRINGDB
CASK
Tchem
Family:  Kinase
Novelty:  0.00856437
Score:  0.998
Data Source:  Reactome,STRINGDB
APBA1
Tbio
Novelty:  0.01126648
Score:  0.977
Data Source:  Reactome,STRINGDB
PPFIA2
Tbio
Novelty:  0.13312014
Score:  0.96
Data Source:  STRINGDB
PPFIA3
Tbio
Novelty:  0.03837299
Score:  0.949
Data Source:  STRINGDB
PPFIA4
Tbio
Novelty:  0.34141709
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Dopamine Neurotransmitter Release Cycle
Neurexins and neuroligins
Neuronal System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
1
1
40.7
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
40.7
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lin-7 homolog A, crumbs cell polarity complex component
VGNC:13203
745401
Macaque
lin-7 homolog A, crumbs cell polarity complex component
697557
Mouse
MGI:2135609
108030
Rat
RGD:621256
85327
Dog
lin-7 homolog A, crumbs cell polarity complex component
VGNC:42686
475412
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lin-7 homolog A, crumbs cell polarity complex component
Macaque
lin-7 homolog A, crumbs cell polarity complex component
Mouse
Rat
Dog
lin-7 homolog A, crumbs cell polarity complex component
Publication Statistics
PubMed Score 45.62
PubMed score by year
PubTator Score 29.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title