Tdark LIN37 Protein lin-37 homolog

Protein Summary

Description

This gene encodes a protein expressed in the eye. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96GY3
• A8KAQ1
• O14557
• Q7Z2T9

Gene Name

• LIN37

Ensembl ID

• ENST00000301159
• ENSP00000301159
• ENSG00000267796

Symbol

• F25965
• lin-37
• ZK418.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
tissue sample	0.62
cell type or tissue	0.57
cell line	0.54
transcription factor	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.25   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 62   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.25   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (59)

Explore Interacting Targets

1 – 10 of 59

• See Interactions on String-DB

LIN9

Tbio

Novelty:  0.01112853

p_int:  1

Score:  0.999

Data Source:  BioPlex,STRINGDB

MYBL2

Tbio

Family:  TF

Novelty:  0.00405647

p_int:  0.99999999

p_ni:  7e-9

p_wrong:  2e-9

Score:  0.997

Data Source:  BioPlex,STRINGDB

LIN52

Tbio

Novelty:  0.08105335

p_int:  0.999999983

p_ni:  1.1e-8

p_wrong:  6e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

LIN54

Tbio

Novelty:  0.06173892

p_int:  0.999999955

p_ni:  4.5e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

MYBL1

Tbio

Family:  TF

Novelty:  0.00695014

p_int:  0.999999903

p_ni:  3.5e-8

p_wrong:  6.3e-8

Score:  0.945

Data Source:  BioPlex,STRINGDB

SCGB1D2

Tbio

Novelty:  0.02178942

p_int:  0.986063071

p_ni:  0.013301668

p_wrong:  0.000635261

Score:  0.187

Data Source:  BioPlex,STRINGDB

RBBP4

Tbio

Novelty:  0.01062843

p_int:  0.933048168

p_ni:  0.066951832

Score:  0.991

Data Source:  BioPlex,STRINGDB

E2F4

Tbio

Family:  TF

Novelty:  0.00317412

Score:  0.975

Data Source:  STRINGDB

RBL1

Tbio

Novelty:  0.00228265

Score:  0.973

Data Source:  STRINGDB

RBL2

Tbio

Novelty:  0.00121893

Score:  0.966

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (15)

Reactome (14)

KEGG (1)

Cell Cycle (R-HSA-1640170)

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5

1 – 5 of 14

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cyclin A:Cdk2-associated events at S phase entry	86 targets	R-HSA-69656
Reactome	Cyclin E associated events during G1/S transition	84 targets	R-HSA-69202
Reactome	G0 and Early G1	27 targets	R-HSA-1538133

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cyclin A:Cdk2-associated events at S phase entry	86 targets	R-HSA-69656
Cyclin E associated events during G1/S transition	84 targets	R-HSA-69202
G0 and Early G1	27 targets	R-HSA-1538133

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Components (2)

Processes (1)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
nucleoplasm	Traceable Author Statement (TAS)	Reactome
transcriptional repressor complex	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
nephrotic syndrome	EFO_0004255	1	1	0	1.9	78.5
creatinine measurement	EFO_0004518	1	1	1		66.8
red blood cell distribution width	EFO_0005192	1	1	1		64.9
thrombomodulin measurement	EFO_0007774	1	1	1		64
glomerular filtration rate	EFO_0005208	1	1	1		62.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
nephrotic syndrome	EFO_0004255	0	1.9	78.5
creatinine measurement	EFO_0004518	1		66.8
red blood cell distribution width	EFO_0005192	1		64.9
thrombomodulin measurement	EFO_0007774	1		64
glomerular filtration rate	EFO_0005208	1		62.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Complete proteome
Isopeptide bond
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
age at first sexual intercourse measurement
creatinine measurement
eosinophil percentage of leukocytes
glomerular filtration rate
mathematical ability
nephrotic syndrome
red blood cell distribution width
self reported educational attainment
thrombomodulin measurement
vitamin D measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	lin-37 DREAM MuvB core complex component	VGNC:2412	748009
Mouse	lin-37 homolog (C. elegans)	MGI:1922910	75660
Rat	lin-37 DREAM MuvB core complex component	RGD:1308901	292787
Dog	lin-37 DREAM MuvB core complex component	VGNC:53734	484575
Horse	lin-37 DREAM MuvB core complex component	VGNC:19675	100051603

Species	Name	OMA	EggNOG	Inparanoid
Chimp	lin-37 DREAM MuvB core complex component
Mouse	lin-37 homolog (C. elegans)
Rat	lin-37 DREAM MuvB core complex component
Dog	lin-37 DREAM MuvB core complex component
Horse	lin-37 DREAM MuvB core complex component

Publication Statistics

PubMed Score 4.25

PubMed score by year

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PubTator Score 0.97

PubTator score by year

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Related Publications

Text Mined References (9)

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10

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PMID	Year	Title