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Tdark
LIN37
Protein lin-37 homolog

Protein Summary
Description
This gene encodes a protein expressed in the eye. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301159
  • ENSP00000301159
  • ENSG00000267796

Symbol
  • F25965
  • lin-37
  • ZK418.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
tissue sample
0.62
cell type or tissue
0.57
cell line
0.54
transcription factor
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.25   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.25   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
LIN9
Tbio
Novelty:  0.01112853
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
MYBL2
Tbio
Family:  TF
Novelty:  0.00405647
p_int:  0.99999999
p_ni:  7e-9
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
LIN52
Tbio
Novelty:  0.08105335
p_int:  0.999999983
p_ni:  1.1e-8
p_wrong:  6e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
LIN54
Tbio
Novelty:  0.06173892
p_int:  0.999999955
p_ni:  4.5e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
MYBL1
Tbio
Family:  TF
Novelty:  0.00695014
p_int:  0.999999903
p_ni:  3.5e-8
p_wrong:  6.3e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
SCGB1D2
Tbio
Novelty:  0.02178942
p_int:  0.986063071
p_ni:  0.013301668
p_wrong:  0.000635261
Score:  0.187
Data Source:  BioPlex,STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
p_int:  0.933048168
p_ni:  0.066951832
Score:  0.991
Data Source:  BioPlex,STRINGDB
E2F4
Tbio
Family:  TF
Novelty:  0.00317412
Score:  0.975
Data Source:  STRINGDB
RBL1
Tbio
Novelty:  0.00228265
Score:  0.973
Data Source:  STRINGDB
RBL2
Tbio
Novelty:  0.00121893
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin E associated events during G1/S transition
Reactome
G0 and Early G1
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition
G0 and Early G1
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.9
78.5
creatinine measurement
1
1
1
66.8
red blood cell distribution width
1
1
1
64.9
thrombomodulin measurement
1
1
1
64
glomerular filtration rate
1
1
1
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
78.5
creatinine measurement
1
66.8
red blood cell distribution width
1
64.9
thrombomodulin measurement
1
64
glomerular filtration rate
1
62.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lin-37 DREAM MuvB core complex component
VGNC:2412
748009
Mouse
MGI:1922910
75660
Rat
RGD:1308901
292787
Dog
lin-37 DREAM MuvB core complex component
VGNC:53734
484575
Horse
lin-37 DREAM MuvB core complex component
VGNC:19675
100051603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lin-37 DREAM MuvB core complex component
Mouse
Rat
Dog
lin-37 DREAM MuvB core complex component
Horse
lin-37 DREAM MuvB core complex component
Publication Statistics
PubMed Score 4.25
PubMed score by year
PubTator Score 0.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title