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Tbio
LIMS2
LIM and senescent cell antigen-like-containing domain protein 2

Protein Summary
Description
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration. This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324938
  • ENSP00000326888
  • ENSG00000072163
  • ENST00000355119
  • ENSP00000347240
  • ENST00000409254
  • ENSP00000386907
  • ENST00000409286
  • ENSP00000386252
  • ENST00000409455
  • ENSP00000386383
  • ENST00000409754
  • ENSP00000386345
  • ENST00000409808
  • ENSP00000386637
  • ENST00000410011
  • ENSP00000387002
  • ENST00000410038
  • ENSP00000386570
  • ENST00000545738
  • ENSP00000443794

Symbol
  • PINCH2
  • LGMD2W
  • PINCH2
  • MDRCMTT
  • PINCH-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
disease perturbation
0.79
PubMedID
0.64
cellular component
0.62
transcription factor
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.11   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.11   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0