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Tbio
LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

Protein Summary
Description
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332345
  • ENSP00000331775
  • ENSG00000169756
  • ENST00000338045
  • ENSP00000337598
  • ENST00000393310
  • ENSP00000376987
  • ENST00000409441
  • ENSP00000387264
  • ENST00000410093
  • ENSP00000386926
  • ENST00000544547
  • ENSP00000437912

Symbol
  • PINCH
  • PINCH1
  • PINCH
  • PINCH1
  • PINCH-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
transcription factor perturbation
0.96
microRNA
0.93
biological process
0.91
transcription factor
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.13   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.13   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
PARVA
Tbio
Novelty:  0.02736601
p_int:  1
Score:  0.996
Data Source:  BioPlex,STRINGDB
PARVB
Tbio
Novelty:  0.03825772
p_int:  0.99999998
p_ni:  1e-8
p_wrong:  1e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
ILK
Tchem
Family:  Kinase
Novelty:  0.00147344
p_int:  0.999999658
p_ni:  3.42e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RSU1
Tbio
Novelty:  0.01645054
p_int:  0.999986818
p_ni:  0.000013182
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PARVG
Tbio
Novelty:  0.08921402
p_int:  0.999962246
p_ni:  0.000037754
Score:  0.951
Data Source:  BioPlex,STRINGDB
CMAS
Tbio
Family:  Enzyme
Novelty:  0.04295627
p_int:  0.998900104
p_ni:  0.001099896
Score:  0.188
Data Source:  BioPlex,STRINGDB
MYO18A
Tbio
Novelty:  0.05058328
p_int:  0.996282476
p_ni:  0.003717524
Score:  0.219
Data Source:  BioPlex,STRINGDB
MYH4
Tbio
Novelty:  0.00556982
p_int:  0.986619105
p_ni:  0.000144174
p_wrong:  0.013236721
Score:  0.294
Data Source:  BioPlex,STRINGDB
RABGAP1
Tbio
Family:  Enzyme
Novelty:  0.14270101
p_int:  0.981258187
p_ni:  0.018741813
Score:  0.15
Data Source:  BioPlex,STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.971619485
p_ni:  0.028380515
Score:  0.314
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Reactome
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
76.2
low density lipoprotein cholesterol measurement
4
4
4
73.7
alkaline phosphatase measurement
2
2
1
6.2
71.6
apolipoprotein B measurement
1
1
1
42.3
Hirsutism
1
1
0
1.3
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
76.2
low density lipoprotein cholesterol measurement
4
73.7
alkaline phosphatase measurement
1
6.2
71.6
apolipoprotein B measurement
1
42.3
Hirsutism
0
1.3
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
LIM zinc finger domain containing 1
694116
Mouse
MGI:1195263
110829
Rat
RGD:1560732
499443
Dog
LIM zinc finger domain containing 1
474540
Horse
LIM zinc finger domain containing 1
VGNC:49480
100060267
Species
Name
OMA
EggNOG
Inparanoid
Macaque
LIM zinc finger domain containing 1
Mouse
Rat
Dog
LIM zinc finger domain containing 1
Horse
LIM zinc finger domain containing 1
Publication Statistics
PubMed Score 163.13
PubMed score by year
PubTator Score 64.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title