Protein Summary
Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000331728
- ENSP00000332687
- ENSG00000182541
- ENST00000333611
- ENSP00000330470
- ENST00000340552
- ENSP00000339916
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.97 | ||
transcription factor perturbation | 0.96 | ||
kinase perturbation | 0.91 | ||
transcription factor | 0.91 | ||
transcription factor binding site profile | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.43 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 525 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.43 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 525 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 103
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (103)
Protein-Protein Interactions (56)
UNC119
Novelty: 0.00396292
p_int: 0.999999974
p_ni: 2.6e-8
Score: 0.252
Data Source: BioPlex,STRINGDB
TTC1
Novelty: 0.01389711
p_int: 0.998995247
p_ni: 0.001004753
Score: 0.187
Data Source: BioPlex,STRINGDB
UBB
Novelty: 0.00661254
p_int: 0.979518773
p_ni: 0.020481227
Score: 0.165
Data Source: BioPlex,STRINGDB
SLC18A1
Family: Transporter
Novelty: 0.01135292
p_int: 0.929132042
p_ni: 0.002316308
p_wrong: 0.06855165
Data Source: BioPlex
TRIM35
Novelty: 0.03280419
p_int: 0.833941311
p_ni: 0.001275066
p_wrong: 0.164783624
Score: 0.18
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (20)
Reactome (11)
KEGG (4)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPHB-mediated forward signaling | ||||
Reactome | RHO GTPase Effectors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPHB-mediated forward signaling | ||||
RHO GTPase Effectors | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 3 | 3 | 92.5 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 91.4 | |||||
red blood cell distribution width | 3 | 3 | 3 | 78.1 | |||||
eosinophil percentage of granulocytes | 1 | 1 | 1 | 68.6 | |||||
reticulocyte count | 3 | 1 | 3 | 63.7 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 92.5 | |||||
eosinophil percentage of leukocytes | 2 | 91.4 | |||||
red blood cell distribution width | 3 | 78.1 | |||||
eosinophil percentage of granulocytes | 1 | 68.6 | |||||
reticulocyte count | 3 | 63.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | LIM domain kinase 2 | VGNC:53399 | 458970 | |||||
Macaque | LIM domain kinase 2 | 716614 | ||||||
Mouse | MGI:1197517 | 16886 | ||||||
Rat | RGD:62056 | 29524 | ||||||
Dog | LIM domain kinase 2 | VGNC:52937 | 486363 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | LIM domain kinase 2 | |||||
Macaque | LIM domain kinase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | LIM domain kinase 2 | |||||
Publication Statistics
PubMed Score 62.43
PubMed score by year
PubTator Score 44.22
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (54)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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