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Tbio
LIMA1
LIM domain and actin-binding protein 1

Protein Summary
Description
Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341247
  • ENSP00000340184
  • ENSG00000050405
  • ENST00000394943
  • ENSP00000378400
  • ENST00000547825
  • ENSP00000448706
  • ENST00000552783
  • ENSP00000448779
  • ENST00000552823
  • ENSP00000450266

Symbol
  • EPLIN
  • SREBP3
  • EPLIN
  • LDLCQ8
  • SREBP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
interacting protein
0.96
disease perturbation
0.93
kinase perturbation
0.93
PubMedID
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.54   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.54   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
GSTK1
Tchem
Family:  Enzyme
Novelty:  0.04205366
p_int:  0.993309424
p_ni:  0.006690576
Score:  0.228
Data Source:  BioPlex,STRINGDB
LRRC39
Tdark
Novelty:  0.70657884
p_int:  0.980078649
p_ni:  0.019921351
Score:  0.327
Data Source:  BioPlex,STRINGDB
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.967296349
p_ni:  0.032703651
Data Source:  BioPlex
MYL6
Tbio
Novelty:  0.00594485
p_int:  0.967270923
p_ni:  0.032729077
Score:  0.394
Data Source:  BioPlex,STRINGDB
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.937591422
p_ni:  0.062408578
Score:  0.358
Data Source:  BioPlex,STRINGDB
PLEKHG6
Tbio
Novelty:  0.15989022
p_int:  0.913224061
p_ni:  0.086775939
Score:  0.227
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.912558767
p_ni:  0.087441233
Data Source:  BioPlex
LSP1
Tbio
Novelty:  0.00889927
p_int:  0.908435677
p_ni:  0.091564323
Score:  0.158
Data Source:  BioPlex,STRINGDB
NEXN
Tbio
Novelty:  0.00745011
p_int:  0.888922616
p_ni:  0.111077384
Score:  0.369
Data Source:  BioPlex,STRINGDB
MYL12B
Tbio
Novelty:  0.00999083
p_int:  0.84271877
p_ni:  0.15728123
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
83.2
myeloid white cell count
1
1
1
75.1
leukocyte count
1
1
1
72.9
diastolic blood pressure
1
1
1
70.8
low density lipoprotein cholesterol measurement
2
1
2
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
83.2
myeloid white cell count
1
75.1
leukocyte count
1
72.9
diastolic blood pressure
1
70.8
low density lipoprotein cholesterol measurement
2
68
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM domain and actin binding 1
VGNC:5453
451892
Macaque
LIM domain and actin binding 1
713519
Mouse
MGI:1920992
65970
Rat
RGD:1564050
300228
Dog
LIM domain and actin binding 1
VGNC:42677
477610
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM domain and actin binding 1
Macaque
LIM domain and actin binding 1
Mouse
Rat
Dog
LIM domain and actin binding 1
Publication Statistics
PubMed Score 44.54
PubMed score by year
PubTator Score 27.66
PubTator score by year
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Related Publications
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PMID
Year
Title