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Tbio
LIM2
Lens fiber membrane intrinsic protein

Protein Summary
Description
Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. This gene encodes an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute to cell junctional organization. It acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221973
  • ENSP00000221973
  • ENSG00000105370
  • ENST00000596399
  • ENSP00000472090

Symbol
  • MP17
  • MP19
  • CTRCT19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
cell type or tissue
0.68
PubMedID
0.56
tissue sample
0.54
cell line
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.59   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.59   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.935493798
p_ni:  0.064506202
Score:  0.194
Data Source:  BioPlex,STRINGDB
HSF4
Tbio
Family:  TF
Novelty:  0.01736563
Score:  0.844
Data Source:  STRINGDB
CRYAA2
Tdark
Novelty:  0.01914081
Score:  0.815
Data Source:  STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
Score:  0.815
Data Source:  STRINGDB
MIP
Tbio
Novelty:  0.00299543
Score:  0.798
Data Source:  STRINGDB
TMEM114
Tdark
Novelty:  0.25895358
Score:  0.763
Data Source:  STRINGDB
CRYBB1
Tbio
Novelty:  0.01083645
Score:  0.758
Data Source:  STRINGDB
CRYBA1
Tbio
Novelty:  0.02788955
Score:  0.748
Data Source:  STRINGDB
CRYBB3
Tbio
Novelty:  0.0455879
Score:  0.748
Data Source:  STRINGDB
BFSP2
Tbio
Novelty:  0.00206411
Score:  0.74
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
47.6
body mass index
2
2
2
46.9
blood protein measurement
1
1
1
31.4
lymphocyte percentage of leukocytes
1
1
1
22.8
1
1
0
1.8
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
47.6
body mass index
2
46.9
blood protein measurement
1
31.4
lymphocyte percentage of leukocytes
1
22.8
0
1.8
9.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lens intrinsic membrane protein 2
VGNC:2323
748793
Mouse
MGI:104698
233187
Rat
RGD:621482
114903
Dog
lens intrinsic membrane protein 2
VGNC:42676
100856095
Horse
lens intrinsic membrane protein 2
VGNC:19666
100066622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lens intrinsic membrane protein 2
Mouse
Rat
Dog
lens intrinsic membrane protein 2
Horse
lens intrinsic membrane protein 2
Publication Statistics
PubMed Score 93.59
PubMed score by year
PubTator Score 56.01
PubTator score by year
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Related Publications
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PMID
Year
Title