LILRB3
Leukocyte immunoglobulin-like receptor subfamily B member 3
Protein Summary
May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
- ENST00000245620
- ENSP00000245620
- ENSG00000204577
- ENST00000391750
- ENSP00000375630
- ENST00000611086
- ENSP00000483625
- ENSG00000274587
- ENST00000613698
- ENSP00000479234
- ENSG00000275019
- ENST00000621210
- ENSP00000484925
- ILT5
- LIR3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.72 | ||
cell line | 0.7 | ||
small molecule perturbation | 0.7 | ||
tissue sample | 0.65 | ||
transcription factor perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 94.92 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 344 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 94.92 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 344 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0