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Tbio
LILRB3
Leukocyte immunoglobulin-like receptor subfamily B member 3

Protein Summary
Description
May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245620
  • ENSP00000245620
  • ENSG00000204577
  • ENST00000391750
  • ENSP00000375630
  • ENST00000611086
  • ENSP00000483625
  • ENSG00000274587
  • ENST00000613698
  • ENSP00000479234
  • ENSG00000275019
  • ENST00000621210
  • ENSP00000484925

Symbol
  • ILT5
  • LIR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
cell line
0.7
small molecule perturbation
0.7
tissue sample
0.65
transcription factor perturbation
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.92   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.92   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0