LILRB2
Leukocyte immunoglobulin-like receptor subfamily B member 2
Protein Summary
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885).
- ENST00000314446
- ENSP00000319960
- ENSG00000131042
- ENST00000391746
- ENSP00000375626
- ENST00000391748
- ENSP00000375628
- ENST00000391749
- ENSP00000375629
- ENST00000434421
- ENSP00000410117
- ENST00000610886
- ENSP00000482933
- ENSG00000276146
- ENST00000614225
- ENSP00000480841
- ENSG00000275463
- ENST00000617341
- ENSP00000484373
- ENST00000617886
- ENSP00000483553
- ENST00000618392
- ENSP00000480302
- ENSG00000274513
- ENST00000618705
- ENSP00000481208
- ENST00000619122
- ENSP00000483478
- ENST00000621020
- ENSP00000483014
- ILT4
- LIR2
- MIR10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.73 | ||
cell line | 0.69 | ||
cell type or tissue | 0.68 | ||
co-expressed gene | 0.61 | ||
PubMedID | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 225.75 (req: < 5)
Gene RIFs: 66 (req: <= 3)
Antibodies: 255 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 225.75 (req: >= 5)
Gene RIFs: 66 (req: > 3)
Antibodies: 255 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0