You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LILRB2
Leukocyte immunoglobulin-like receptor subfamily B member 2

Protein Summary
Description
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314446
  • ENSP00000319960
  • ENSG00000131042
  • ENST00000391746
  • ENSP00000375626
  • ENST00000391748
  • ENSP00000375628
  • ENST00000391749
  • ENSP00000375629
  • ENST00000434421
  • ENSP00000410117
  • ENST00000610886
  • ENSP00000482933
  • ENSG00000276146
  • ENST00000614225
  • ENSP00000480841
  • ENSG00000275463
  • ENST00000617341
  • ENSP00000484373
  • ENST00000617886
  • ENSP00000483553
  • ENST00000618392
  • ENSP00000480302
  • ENSG00000274513
  • ENST00000618705
  • ENSP00000481208
  • ENST00000619122
  • ENSP00000483478
  • ENST00000621020
  • ENSP00000483014

Symbol
  • ILT4
  • LIR2
  • MIR10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
cell line
0.69
cell type or tissue
0.68
co-expressed gene
0.61
PubMedID
0.53


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.75   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.75   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (302)
LILRA3
Tdark
p_int:  0.999999999
p_wrong:  1e-9
Data Source:  BioPlex
LILRB4
Tbio
Novelty:  0.01443658
p_int:  0.785162863
p_ni:  1.6e-8
p_wrong:  0.214837121
Score:  0.601
Data Source:  BioPlex,STRINGDB
HLA-G
Tbio
Novelty:  0.0009462
Score:  0.998
Data Source:  STRINGDB
B2M
Tbio
Novelty:  0.00011248
Score:  0.99
Data Source:  Reactome,STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.977
Data Source:  STRINGDB
HLA-F
Tbio
Novelty:  0.01200285
Score:  0.973
Data Source:  STRINGDB
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.967
Data Source:  STRINGDB
P10316
Tbio
Novelty:  0.00270731
Score:  0.966
Data Source:  STRINGDB
P30455
Tbio
Novelty:  0.00270731
Score:  0.966
Data Source:  STRINGDB
P30512
Tbio
Novelty:  0.00270731
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Mutant Phenotype (IMP)
ARUK-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (368)
Items per page:
1 – 5 of 368
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
36
18
49
98.9
high density lipoprotein cholesterol measurement
36
18
49
98.9
high density lipoprotein cholesterol measurement
36
18
49
98.9
high density lipoprotein cholesterol measurement
36
18
49
98.9
creatine kinase measurement
5
5
9
98.4
Items per page:
1 – 5 of 368
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
49
98.9
high density lipoprotein cholesterol measurement
49
98.9
high density lipoprotein cholesterol measurement
49
98.9
high density lipoprotein cholesterol measurement
49
98.9
creatine kinase measurement
9
98.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 225.75
PubMed score by year
Related Publications
No publications found