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Tbio
LILRB1
Leukocyte immunoglobulin-like receptor subfamily B member 1

Protein Summary
Description
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251). This gene is a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000448689
  • ENSP00000409968
  • ENSG00000104972
  • ENST00000612636
  • ENSP00000479887
  • ENSG00000277807
  • ENST00000616408
  • ENSP00000481700
  • ENSG00000274669
  • ENST00000617686
  • ENSP00000478282
  • ENST00000618055
  • ENSP00000480365
  • ENST00000618681
  • ENSP00000479753

Symbol
  • ILT2
  • LIR1
  • MIR7
  • ILT2
  • LIR1
  • MIR7
  • PIRB
  • CD85J
  • ILT-2
  • LIR-1
  • MIR-7
  • PIR-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.81
biological term
0.77
tissue sample
0.68
cell line
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.88   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.88   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0