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Tbio
LILRA5
Leukocyte immunoglobulin-like receptor subfamily A member 5

Protein Summary
Description
May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition. The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000432233
  • ENSP00000404236
  • ENSG00000187116
  • ENST00000486742
  • ENSP00000484372
  • ENST00000611164
  • ENSP00000482658
  • ENSG00000278355
  • ENST00000612266
  • ENSP00000480436
  • ENSG00000274914
  • ENST00000612621
  • ENSP00000484785
  • ENST00000613559
  • ENSP00000484775
  • ENST00000614299
  • ENSP00000483992
  • ENST00000615820
  • ENSP00000480204
  • ENSG00000274113
  • ENST00000616133
  • ENSP00000484062
  • ENSG00000275404
  • ENST00000618711
  • ENSP00000478354
  • ENST00000619516
  • ENSP00000480382
  • ENST00000620091
  • ENSP00000480458
  • ENST00000620692
  • ENSP00000483958
  • ENST00000620898
  • ENSP00000484869
  • ENST00000621042
  • ENSP00000482882
  • ENST00000621482
  • ENSP00000477785

Symbol
  • ILT11
  • LILRB7
  • LIR9
  • CD85
  • LIR9
  • CD85F
  • ILT11
  • LIR-9
  • ILT-11
  • LILRB7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.62
tissue
0.59
cell line
0.57
kinase perturbation
0.54
transcription factor
0.47


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.14   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.14   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
HLA-G
Tbio
Novelty:  0.0009462
Score:  0.922
Data Source:  STRINGDB
HLA-F
Tbio
Novelty:  0.01200285
Score:  0.921
Data Source:  STRINGDB
HLA-E
Tbio
Novelty:  0.00216583
Score:  0.919
Data Source:  STRINGDB
Q31610
Tbio
Novelty:  0.00790207
Score:  0.909
Data Source:  STRINGDB
P30488
Tbio
Novelty:  0.00790207
Score:  0.909
Data Source:  STRINGDB
P30490
Tbio
Novelty:  0.00790207
Score:  0.909
Data Source:  STRINGDB
P30491
Tbio
Novelty:  0.00790207
Score:  0.909
Data Source:  STRINGDB
P30495
Tbio
Novelty:  0.00790207
Score:  0.909
Data Source:  STRINGDB
P30685
Tbio
Novelty:  0.00790207
Score:  0.909
Data Source:  STRINGDB
P30485
Tbio
Novelty:  0.00790207
Score:  0.909
Data Source:  STRINGDB
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (66)
Items per page:
1 – 5 of 66
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
12
10
25
99
high density lipoprotein cholesterol measurement
12
10
25
99
high density lipoprotein cholesterol measurement
12
10
25
99
apolipoprotein A 1 measurement
2
5
5
97.6
apolipoprotein A 1 measurement
2
5
5
97.6
Items per page:
1 – 5 of 66
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
25
99
high density lipoprotein cholesterol measurement
25
99
high density lipoprotein cholesterol measurement
25
99
apolipoprotein A 1 measurement
5
97.6
apolipoprotein A 1 measurement
5
97.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3647196
232801
Rat
RGD:1582781
691533
Publication Statistics
PubMed Score 10.14
PubMed score by year
PubTator Score 17.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title