Tbio LILRA4 Leukocyte immunoglobulin-like receptor subfamily A member 4

Protein Summary

Description

Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed:24586760). This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P59901
• Q32MC4

Gene Name

• LILRA4

Ensembl ID

• ENST00000291759
• ENSP00000291759
• ENSG00000239961
• ENST00000613813
• ENSP00000479979
• ENSG00000277092
• ENST00000616790
• ENSP00000483846
• ENSG00000274185
• ENST00000619832
• ENSP00000481073
• ENSG00000276798

Symbol

• ILT7
• ILT7
• CD85g

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.72
kinase perturbation	0.66
protein domain	0.58
tissue sample	0.57
tissue	0.54

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Leukocyte Immunoglobulin-like Receptor Subfamily A Member 4

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Leukocyte Immunoglobulin-like Receptor Subfamily A Member 4

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Leukocyte Immunoglobulin-like Receptor Subfamily A Member 4

Protein / ... / Protease Inhibitor / Leukocyte Immunoglobulin-like Receptor Subfamily A Member 4

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Leukocyte Immunoglobulin-like Receptor Subfamily A Member 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.98   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.98   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0