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Tbio
LILRA1
Leukocyte immunoglobulin-like receptor subfamily A member 1

Protein Summary
Description
May act as receptor for class I MHC antigens. This gene encodes an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251372
  • ENSP00000251372
  • ENSG00000104974
  • ENST00000453777
  • ENSP00000413715
  • ENST00000617170
  • ENSP00000477637
  • ENSG00000275525
  • ENST00000620606
  • ENSP00000478666
  • ENST00000628480
  • ENSP00000487229
  • ENSG00000277398
  • ENST00000631007
  • ENSP00000487011
  • ENSG00000274935

Symbol
  • LIR6
  • LIR6
  • CD85I
  • LIR-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
tissue sample
0.73
cell line
0.65
cell type or tissue
0.62
protein domain
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (135)
LILRA3
Tdark
p_int:  0.999999325
p_ni:  1e-9
p_wrong:  6.75e-7
Data Source:  BioPlex
HLA-G
Tbio
Novelty:  0.0009462
Score:  0.937
Data Source:  STRINGDB
HLA-F
Tbio
Novelty:  0.01200285
Score:  0.937
Data Source:  STRINGDB
P30504
Tbio
Novelty:  0.00698601
Score:  0.935
Data Source:  STRINGDB
P30505
Tbio
Novelty:  0.00698601
Score:  0.935
Data Source:  STRINGDB
P30508
Tbio
Novelty:  0.00698601
Score:  0.935
Data Source:  STRINGDB
Q29963
Tbio
Novelty:  0.00698601
Score:  0.935
Data Source:  STRINGDB
Q95604
Tbio
Novelty:  0.00698601
Score:  0.935
Data Source:  STRINGDB
Q29960
Tbio
Novelty:  0.00698601
Score:  0.935
Data Source:  STRINGDB
P04222
Tbio
Novelty:  0.00698601
Score:  0.935
Data Source:  STRINGDB
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
37.4
blood protein measurement
1
1
1
37.4
blood protein measurement
1
1
1
37.4
blood protein measurement
1
1
1
37.4
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
37.4
blood protein measurement
1
37.4
blood protein measurement
1
37.4
blood protein measurement
1
37.4
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 5.19
PubMed score by year
PubTator Score 4.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title