Protein Summary
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- ENST00000263274
- ENSP00000263274
- ENSG00000105486
- ENST00000427526
- ENSP00000442841
- ENST00000601091
- ENSP00000471836
- ENST00000613670
- ENSP00000483027
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
ligand (protein) perturbation | 0.99 | ||
histone modification site profile | 0.93 | ||
molecular function | 0.93 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.71 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 492 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 285.71 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 492 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (329)
RNF166
Novelty: 0.71460884
p_int: 0.999998636
p_ni: 0.000001297
p_wrong: 6.7e-8
Score: 0.34
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (45)
Reactome (32)
KEGG (4)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Base Excision Repair | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Chromosome Maintenance | ||||
Reactome | DNA Repair | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Base Excision Repair | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Chromosome Maintenance | ||||
DNA Repair | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (5)
Components (5)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
refractive error measurement | 1 | 1 | 1 | 46.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
refractive error measurement | 1 | 46.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DNA ligase 1 | VGNC:10202 | 468936 | |||||
Macaque | DNA ligase 1 | 718528 | ||||||
Mouse | MGI:101789 | 16881 | ||||||
Rat | RGD:6491367 | 100911727 | ||||||
Dog | DNA ligase 1 | VGNC:42673 | 100686967 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DNA ligase 1 | |||||
Macaque | DNA ligase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | DNA ligase 1 | |||||
Publication Statistics
PubMed Score 285.71
PubMed score by year
PubTator Score 46.70
PubTator score by year
Related Publications
Text Mined References (87)
GeneRif Annotations (37)
Items per page:
0 of 0
PMID | Year | Title |
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