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Tbio
LIF
Leukemia inhibitory factor

Protein Summary
Description
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249075
  • ENSP00000249075
  • ENSG00000128342
  • ENST00000403987
  • ENSP00000384450

Symbol
  • HILDA
  • CDF
  • DIA
  • HILDA
  • MLPLI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.93
gene perturbation
0.93
PubMedID
0.93
phenotype
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 803.47   (req: < 5)
Gene RIFs: 155   (req: <= 3)
Antibodies: 546   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 803.47   (req: >= 5)
Gene RIFs: 155   (req: > 3)
Antibodies: 546   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (200)
IL6ST
Tclin
Novelty:  0.01026472
Score:  0.993
Data Source:  Reactome,STRINGDB
LIFR
Tbio
Novelty:  0.00514085
Score:  0.988
Data Source:  Reactome,STRINGDB
CTF1
Tbio
Novelty:  0.00383692
Score:  0.979
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.973
Data Source:  STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.953
Data Source:  STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.952
Data Source:  STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.951
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.95
Data Source:  Reactome,STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.943
Data Source:  STRINGDB
HBEGF
Tbio
Novelty:  0.00105355
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
1 – 5 of 17
IL2RG
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL2RB
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
MPL
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
Pathways (29)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
4
4
2
1.1
88
cup-to-disc ratio measurement
2
2
2
81.8
heel bone mineral density
2
2
4
73.4
2
2
1
1.1
69.8
2
2
1
1.2
68.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
1.1
88
cup-to-disc ratio measurement
2
81.8
heel bone mineral density
4
73.4
1
1.1
69.8
1
1.2
68.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIF, interleukin 6 family cytokine
VGNC:14779
736309
Mouse
MGI:96787
16878
Rat
RGD:620865
60584
Dog
LIF, interleukin 6 family cytokine
VGNC:42671
403449
Cow
LIF, interleukin 6 family cytokine
VGNC:30880
280840
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIF, interleukin 6 family cytokine
Mouse
Rat
Dog
LIF, interleukin 6 family cytokine
Cow
LIF, interleukin 6 family cytokine
Publication Statistics
PubMed Score 803.47
PubMed score by year
PubTator Score 2484.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title